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Inhibitor of mitochondrial division
BML-CM127-0010 10 mg 113.00 USD
BML-CM127-0050 50 mg 459.00 USD
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Mdivi-1 is a selective inhibitor of mitochondrial division in yeast and mammalian cells which acts via inhibiting the mitochondrial division dynamin. In cells, Mdivi-1 inhibits apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 causes the rapid (<5 min) reversible and dose-dependent formation of net-like mitochondria in wild-type cells with an IC50= ~10µM. In yeast, time-lapse fluorescence microscopy revealed no detectable mitochondrial division after treatment with Mdivi-1. It inhibits Dnm1 GTPase activity in a dose dependent manner with an estimated IC50 of 1-10µM but is not a general inhibitor of GTPases.

Product Details

Purity:≥97% (HPLC)
Identity:Determined by 1H-NMR.
Appearance:White solid.
Solubility:Soluble in DMSO (25mg/ml).
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival: Y. Song, et al.; Autophagy 1080, 15548627 (2021), Abstract;
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors: M. Zille, et al.; eNeuro 6, ENEURO.0263-18.2019 (2019), Abstract; Full Text
Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model: J.E. Bae, et al.; Cell Death Dis. 10, 952 (2019), Abstract; Full Text
Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells: A. Hogue, et al.; Cell Death Discov. 4, 39 (2018), Abstract; Full Text
PGAM5 regulates PINK1/Parkin-mediated mitophagy via DRP1 in CCCP-induced mitochondrial dysfunction: Y.S. Park, et al.; Toxicol. Lett. 284, 120 (2017), Abstract;
Effect of mitochondrial fission inhibition on C2C12 differentiation: D. Bloemberg, et al.; Data Brief 7, 634 (2016), Application(s): Cell culture, Abstract; Full Text
Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after X-irradiation: T. Yamomori, et al.; Mol. Biol. Cell 26, 4607 (2015), Application(s): Cell Culture, Abstract; Full Text
Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling: Y.J. Kang, et al.; Nat. Commun. 6, 8371 (2015), Application(s): Cell culture, Abstract;
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization: A. Cassidy-Stone et al.; Dev. Cell 14, 193 (2008), Abstract;

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