Embelin is a novel cell-permeable inhibitor of XIAP (X-linked inhibitor of apoptosis) which was discovered by screening a library of natural products derived from traditional Chinese medicine. It binds to the XIAP BIR3 domain preventing its binding to and inhibition of caspase-9 and effector caspases. Embelin selectively inhibits cell growth in cancer cells expressing high levels of XIAP (IC50 = 3-6 µM) versus normal cells with low levels of XIAP.
Product Details
| Alternative Name: | Embelic acid |
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| Formula: | C17H26O4 |
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| MW: | 294.4 |
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| CAS: | 550-24-3 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Orange crystalline solid. |
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| Solubility: | Soluble in DMSO (10mg/ml) |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database: Z. Nikolovska-Coleska et al.; J. Med. Chem.
47, 2430 (2004),
Abstract;
