An analog of antimycin A (mixture of antimycin A1, A2, A3 and A4) which binds to the hydrophobic groove of Bcl-2 and Bcl-XL thereby inducing apoptosis. It displays selective cytotoxicity for Bcl-XL-expressing cells (10µg/ml). Unlike antimycin A it does not exhibit general mitochondrial toxicity.
Product Details
| Formula: | C27H38N2O9 |
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| MW: | 534.6 |
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| Purity: | ≥85% |
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| Appearance: | White solid. |
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| MeltingPoint: | 63.5-65°C |
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| Solubility: | Soluble in DMSO (12 mg/ml) or ethanol (12 mg/ml) |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at-20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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2-Methoxy-antimycin A1
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Product Literature References
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell Biol.
3, 183 (2001),
Abstract;
A model of antimycin A binding based on structure-activity studies of synthetic antimycin A analogues: H. Miyoshi, et al.; Biochim. Biophys. Acta
1229, 149 (1995),
Abstract;
Structural factors of antimycin A molecule required for inhibitory action: N. Tokutake, et al.; Biochim. Biophys. Acta
1185, 271 (1994),
Abstract;
