A potent reversible inhibitor of mitochondrial oxidative phosphorylation. FCCP is a useful tool for depolarizing mitochondrial membrane potential. Treatment of cells with FCCP at varying concentrations leads to partial (100 nM) or complete (10 µM) depolarization and apoptosis.
Product Details
| Alternative Name: | Carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone |
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| Formula: | C10H5F3N4O |
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| MW: | 254.2 |
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| CAS: | 370-86-5 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells: W.F. Alpaugh, et al.; Cells
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Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination: Y. Oshima, et al.; J. Cell Biol.
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Abstract;
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats: J.C.B. Ferreira, et al.; Nat. Commun.
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Abstract;
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A moderate but not total decrease of mitochondrial membrane potential triggers apoptosis in neuron-like cells: I. Gautier, et al.; Neuroreport
11, 2953 (2000),
Abstract;
Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization: T. J. Collins, et al.; Biochem. J.
347, 593 (2000),
Abstract;
Full Text
Staining of mitochondrial membranes with 10-nonyl acridine orange, MitoFluor Green, and MitoTracker Green is affected by mitochondrial membrane potential altering drugs: J. F. Keij, et al.; Cytometry
39, 203 (2000),
Abstract;
