A potent reversible inhibitor of mitochondrial oxidative phosphorylation. FCCP is a useful tool for depolarizing mitochondrial membrane potential. Treatment of cells with FCCP at varying concentrations leads to partial (100 nM) or complete (10 µM) depolarization and apoptosis.
Product Specification
Alternative Name: | Carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone |
|
Formula: | C10H5F3N4O |
|
MW: | 254.2 |
|
CAS: | 370-86-5 |
|
Purity: | ≥98% (HPLC) |
|
Identity: | Determined by 1H-NMR. |
|
Appearance: | Yellow solid. |
|
Solubility: | Soluble in DMSO |
|
Shipping: | Ambient |
|
Long Term Storage: | Ambient |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over
Product Literature References
A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats: J.C.B. Ferreira, et al.; Nat. Commun.
10, 329 (2019),
Abstract;
Full Text
A moderate but not total decrease of mitochondrial membrane potential triggers apoptosis in neuron-like cells: I. Gautier, et al.; Neuroreport
11, 2953 (2000),
Abstract;
Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization: T. J. Collins, et al.; Biochem. J.
347, 593 (2000),
Abstract;
Full Text
Staining of mitochondrial membranes with 10-nonyl acridine orange, MitoFluor Green, and MitoTracker Green is affected by mitochondrial membrane potential altering drugs: J. F. Keij, et al.; Cytometry
39, 203 (2000),
Abstract;