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MPTP inhibitor
BML-CM120-0010 10 mg 111.00 USD
BML-CM120-0050 50 mg 431.00 USD
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A potent reversible inhibitor of mitochondrial oxidative phosphorylation. FCCP is a useful tool for depolarizing mitochondrial membrane potential. Treatment of cells with FCCP at varying concentrations leads to partial (100 nM) or complete (10 µM) depolarization and apoptosis.

Product Details

Alternative Name:Carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone
Purity:≥98% (HPLC)
Identity:Determined by 1H-NMR.
Appearance:Yellow solid.
Solubility:Soluble in DMSO
Shipping:Ambient Temperature
Long Term Storage:Ambient
Regulatory Status:RUO - Research Use Only
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Product Literature References

Autophagy deficiency abolishes liver mitochondrial DNA segregation: K. Tostes, et al.; Autophagy 1080, 15548627 (2022), Abstract;
Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts: D.M. Booth, et al.; STAR Protoc. 3, 101119 (2022), Abstract; Full Text
Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome: I.A. Khatib, et al.; J. Biol. Chem. 298, 102420 (2022), Abstract;
Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells: W.F. Alpaugh, et al.; Cells 10, 2265 (2021), Abstract;
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination: Y. Oshima, et al.; J. Cell Biol. 220, 202006043 (2021), Abstract;
A selective inhibitor of mitofusin 1-╬▓IIPKC association improves heart failure outcome in rats: J.C.B. Ferreira, et al.; Nat. Commun. 10, 329 (2019), Abstract; Full Text
A moderate but not total decrease of mitochondrial membrane potential triggers apoptosis in neuron-like cells: I. Gautier, et al.; Neuroreport 11, 2953 (2000), Abstract;
Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization: T. J. Collins, et al.; Biochem. J. 347, 593 (2000), Abstract; Full Text
Staining of mitochondrial membranes with 10-nonyl acridine orange, MitoFluor Green, and MitoTracker Green is affected by mitochondrial membrane potential altering drugs: J. F. Keij, et al.; Cytometry 39, 203 (2000), Abstract;

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