Potent, selective inhibitor of mitochondrial Na+Ca2+ exchange. IC50=0.4µM. Blocks mitochondrial permeability transition.
Product Details
| Formula: | C15H11Cl2NOS |
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| MW: | 324.2 |
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| CAS: | 75450-34-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
MICU1 Confers Protection from MCU-Dependent Manganese Toxicity: J. Wettmarchausen, et al.; Cell Rep.
25, 1425 (2018),
Abstract;
Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart: S. De La Fuente, et al.; Cell Rep.
24, 3099 (2018),
Abstract;
Mitochondria fine-tune the slow Ca2+ transients induced by electrical stimulation of skeletal myotubes: V. Eisner, et al.; Cell Calcium
48, 358 (2010),
Abstract;
Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157: D. A. Cox, et al.; J. Cardiovasc. Pharmacol.
21, 595 (1993),
Abstract;
