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Oligomycin A

ATPase inhibitor



BML-CM111-0005	5 mg	218.00 USD

BML-CM111-0025	25 mg	908.00 USD
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Replaces Prod. #: ALX-380-036

Inhibits mitochondrial ATPases (F₁F₀). Stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Induces autophagy in the IPLB-LdFB insect cell line.

Product Details

Formula:	C₄₅H₇₄O₁₁

MW:	791.1

CAS:	579-13-5

MI:	14: 6833

RTECS:	RK3328000

Purity:	≥97% (HPLC, TLC)

Appearance:	White solid.

Solubility:	Soluble in DMSO (300mg/ml), 100% ethanol (200mg/ml) or acetone (800mg/ml).

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome: I.A. Khatib, et al.; J. Biol. Chem. 298, 102420 (2022), Abstract;

Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells: W.F. Alpaugh, et al.; Cells 10, 2265 (2021), Abstract;

Unique metabolic phenotype and its transition during maturation of juvenile male germ cells: A.L. Voigt, et al.; FASEB J. 35, 21513 (2021), Abstract;

Oligomycin A induces autophagy in the IPLB-LdFB insect cell line: G. Tettamanti, et al.; Cell Tissue Res. 326, 179 (2006), Abstract;

Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004), Abstract;

Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2002), Abstract;

The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000), Abstract;

Acidification of rat liver lysosomes: quantitation and comparison with endosomes: R.W. Van Dyke; Am. J. Physiol. 265, C901 (1993), Abstract;

Inhibitors of the ATP synthethase system: P.E. Linnett & R.B. Beechey; Methods Enzymol. 55, 472 (1979), Abstract;