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United States 

Bafilomycin A1

ATPase inhibitor
BML-CM110-0100 100 µg 194.00 USD
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Replaces Prod. #: ALX-380-030

Macrolide antibiotic that acts as a potent and selective inhibitor of vacuolar-type H+-ATPase (V-type) (IC50=004-0.4nmol/mg). Valuable tool for distinguishing among different types of ATPases. Inhibitor of endosomal acidification.¨Blocks lysosomal cholesterol trafficking in macrophages. Blocks pH regulation in brain cells.

Product Details

Purity:≥95% (HPLC, TLC)
Appearance:White powder to colorless film.
Solubility:Soluble in 100% ethanol, methanol or DMSO.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light.
Technical Info/Product Notes:Typical concentrations for use in cell culture are 50-100nM.
Note: Product is not sterile.
Regulatory Status:RUO - Research Use Only
BML-CM110 structure
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BML-CM110 structure

Product Literature References

ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections: B. Ramnan, et al.; Viruses 13, 315 (2021), Abstract; Full Text
Contribution of Particle-Induced Lysosomal Membrane Hyperpolarization to Lysosomal Membrane Permeabilization: T. Ziglari, et al.; Int. J. Mol. Sci. 22, 2277 (2021), Abstract; Full Text
GSK3B induces autophagy by phosphorylating ULK1: H.Y. Ryu, et al.; Exp. Mol. Med. 53, 369 (2021), Abstract;
Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy: T.A. Giovannucci, et al.; Autophagy 5, 1554862 (2021), Abstract;
Macrophage autophagy protects against hepatocellular carcinogenesis in mice: A. Deust, et al.; Sci. Rep. 11, 18809 (2021), Abstract;
Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons: Z. Hanss, et al.; Mov. Disord. 36, 704 (2021), Application(s): Treatment of iPSCs-derived neurons, Abstract; Full Text
Perturbation of Cellular Redox Homeostasis Dictates Divergent Effects of Polybutyl Cyanoacrylate (PBCA) Nanoparticles on Autophagy: T. Sønstevold, et al.; Cells 10, 3432 (2021), Abstract;
Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson’s Disease: I. Maestro, et al.; ACS Chem. Neurosci. 12, 4512 (2021), Abstract;
TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells: B. Relic, etr al.; Biochem. J. 478, 3099 (2021), Abstract;
The SZT2 Interactome Unravels New Functions of the KICSTOR Complex: C. Cattelani, et al.; Cells 10, 2711 (2021), Abstract;
Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology: W. El Manaa, et al.; Autophagy 17, 4363 (2021), Abstract;
AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy: M. Dohmen, et al.; Nat. Commun. 11, 1032 (2020), Abstract; Full Text
K63-linked ubiquitylation induces global sequestration of mitochondria: T.J.C. Richard, et al.; Sci. Rep. 10, 22334 (2020), Abstract; Full Text
Lysosomal dysfunction and autophagy blockade contribute to MDMA-induced neurotoxicity in SH-SY5Y neuroblastoma cells: I.H. Li, et al.; Chem. Res. Toxicol. 33, 903 (2020), Abstract;
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis: D. Santovito, et al. ; Sci. Transl. Med. 12, eaaz2294 (2020), Abstract;
Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment: A. Dumont, et al.; Cell Death Dis. 10, 485 (2019), Abstract; Full Text
Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells: R.Willbold, et al.; Cell Death Dis. 10, 601 (2019), Abstract; Full Text
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models: M.C. Silva, et al.; Elife 8, e45457 (2019), Abstract; Full Text
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation: C. Sheng, et al.; Nat Commun. 9, 4047 (2018), Abstract; Full Text
Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death: P. Szalai, et al.; Cell Calcium 76, 48 (2018), Abstract;
Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis: B. Carroll, et al.; Nat. Commun. 9, 256 (2018), Abstract; Full Text
The IAP family member BRUCE regulates autophagosome-lysosome fusion: P. Ebner, et al.; Nat. Commun. 9, 599 (2018), Abstract; Full Text
Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo: M. Lehmann, et al.; Eur. Respir. J. 50, 1602367 (2017), Abstract; Full Text
Identification of V-ATPase as a molecular sensor of SOX11-levels and potential therapeutic target for mantle cell lymphoma: V.K. Emruli, et al.; BMC Cancer 16, 493 (2016), Application(s): Transient knock-down of V-ATPase, Abstract; Full Text
Legionella pneumophilaS1P-lyase targets host sphingolipid metabolism and restrains autophagy: M. Rolando, et al.; PNAS 113, 1901 (2016), Abstract; Full Text
Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS: P. Ziltener, et al.; PLoS One 12, e1005591 (2016), Application(s): Cell culture, Abstract; Full Text
Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition: D. Park, et al.; Sci. Rep. 6, 21772 (2016), Application(s): Cell culture, Abstract; Full Text
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair: G. Hewitt, et al.; Autophagy 12, 1917 (2016), Abstract; Full Text
Pharmacological Inhibition of ULK1 Blocks mTOR-Dependent Autophagy: K. J. Petherick, et al.; J. Biol. Chem. 290, 11376 (2015), Application(s): Cell Culture, Abstract; Full Text
Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry: A.M. Schläfli, et al.; Eur. J. Histochem. 59, 137 (2015), Application(s): Cell Culture, Abstract; Full Text
Revealing the fate of cell surface human P-glycoprotein (ABCB1): The Lysosomal Degradation Pathway: K. Katayama, et al.; Biochim. Biophys. Acta 1853, 2361 (2015), Application(s): Cell Culture, Abstract;
The role of cytoplasmic-to-lysosomal pH gradient in hydrophobic weak base drug sequestration in lysosomes: B. Zhitomirsky, et al.; Cancer Cell Microenviron. 2, e807 (2015), Application(s): Cell Culture, Fluorescence Microscopy, Full Text
Inhibition of GATE-16 attenuates ATRA-induced neutrophil differentiation of APL cells and interferes with autophagosome formation: D. Brigger, et al.; Biochem. Biophys. Res. Commun. 438, 283 (2013), Application(s): Fluorescence Microscopy, PCR, WB, Abstract;
The (pro)renin receptor ((P)RR) can act as a repressor of Wnt signalling: S.M. Bernhard, et al.; Biochem. Pharmacol. 84, 1643 (2012), Application(s): WB, Cell Lysis, Abstract;
Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006), Review, Abstract;
Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator: T. Okiyoneda, et al.; Biochim. Biophys. Acta 1763, 1017 (2006), Abstract;
Reduced capacitative calcium entry correlates with vesicle accumulation and apoptosis: S. Jaydev, et al.; J. Biol. Chem. 274, 8261 (1999), Abstract;
Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Dröse & K. Altendorf; J. Exp. Biol. 200, 1 (1997), Abstract;
Inhibition of mitogen-induced DNA synthesis by bafilomycin A1 in Swiss 3T3 fibroblasts: A.J. Saurin, et al.; Biochem. J. 313, 65 (1996), Abstract;
Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases: J. Knops, et al.; J. Biol. Chem. 270, 2419 (1995), Abstract; Full Text
Inositol trisphosphate-dependent and -independent Ca2+ mobilization pathways at the vacuolar membrane of Candida albicans: C.M. Calvert & D. Sanders; J. Biol. Chem. 270, 7272 (1995), Abstract; Full Text
Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death: T. Nishihara, et al.; BBRC 212, 255 (1995), Abstract;
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein: C. Haass, et al.; J. Biol. Chem. 270, 6186 (1995), Abstract; Full Text
Active vacuolar H+ATPase is required for both endocytic and exocytic processes during viral infection of BHK-21 cells: H. Palokangas, et al.; J. Biol. Chem. 269, 17577 (1994), Abstract; Full Text
Bafilomycin inhibits proton flow through the H+ channel of vacuolar proton pumps: B.P. Crider, et al.; J. Biol. Chem. 269, 17379 (1994), Abstract; Full Text
A depolarization-stimulated, bafilomycin-inhibitable H+ pump in hippocampal astrocytes: C.A. Pappas & B.R. Ransom; Glia 9, 280 (1993), Abstract;
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, blocks lysosomal cholesterol trafficking in macrophages: T. Furuchi, et al.; J. Biol. Chem. 268, 27345 (1993), Abstract; Full Text
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993), Abstract;
Bafilomycin A1 inhibits the targeting of lysosomal acid hydrolases in cultured hepatocytes: K. Oda, et al.; BBRC 178, 369 (1991), Abstract;
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells: T. Yoshimori, et al.; J. Biol. Chem. 266, 17707 (1991), Abstract; Full Text
Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption: K. Sundqui, et al.; BBRC 168, 309 (1990), Abstract;
Kinetic studies of chromaffin granule H+-ATPase and effects of bafilomycin A1: H. Hanada, et al.; BBRC 170, 873 (1990), Abstract;
The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase: T. Umata, et al.; J. Biol. Chem. 265, 21940 (1990), Abstract; Full Text
The evolution of H+-ATPases [see comments]: N. Nelson & L. Taiz; TIPS 14, 113 (1989), (Review), Abstract;
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells: E.J. Bowman, et al.; PNAS 85, 7972 (1988), Abstract;
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. 37, 110 (1984), Abstract;

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