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GlcNAc phosphotransferase inhibitor
BML-CC104-0010 10 mg 221.00 USD
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Replaces Prod. #: ALX-380-047

Nucleoside antibiotic. Inhibits protein N-glycosylation by blocking the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate.  Induces ER-stress following the inhibition of N-linked glycosylation. Arrests cell cycle in late G1. Unstable at acidic pH.

Product Details

Formula:C38H62N4O16 (Tun B)
MW:Avg. 840.0
Source:Isolated from Streptomyces lysosuperficus.
MI:14: 9819
Purity:≥99% (TLC)
Purity Detail:Mixture of tunicamycin A, B, C and D.
Appearance:White solid to tan solid.
Solubility:Soluble in DMSO (>10mg/ml) or methanol (5mg/ml; warm).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Technical Info/Product Notes:Replacement for ADI-908-297.
Regulatory Status:RUO - Research Use Only
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Product Literature References

ER stress-induced cell death proceeds independently of the TRAIL-R2 signaling axis in pancreatic β cells: C. Hagenlocher, et al.; Cell Death Discov. 8, 34 (2022), Abstract;
CHOP favors endoplasmic reticulum stress-induced apoptosis in hepatocellular carcinoma cells via inhibition of autophagy: Y. Lei, et al.; PLoS One 12, e0183680 (2017), Abstract; Full Text
Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells: C.A. Tang, et al.; Cancer Res. 76, 2137 (2016), Application(s): Stimulated cells, Abstract; Full Text
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response: A. De Gassart, et al.; PNAS 113, E117 (2016), Application(s): Cell culture, Abstract; Full Text
Anti-Inflammatory Activity of Cyanobacterial Serine Protease Inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in Human Hepatoma Cell Line Huh7 and Effects in Zebrafish (Danio rerio): S. Faltermann, et al.; Toxins (Basel) 8, 219 (2016), Application(s): EROD assay in Huh7 Cells; Zebrafishliver organ culture and gene expression analysis, Abstract; Full Text
Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway: K. Shenderov, et al.; J. Immunol. 192, 2029 (2014), Abstract;
Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin: T. Yoshida, et al.; Oncol. Rep. 18, 1239 (2007), Abstract;
Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response: C.C. Jiang, et al.; Cancer Res. 67, 5880 (2007), Abstract;
Novel potential of tunicamycin as an activator of the aryl hydrocarbon receptor -- dioxin responsive element signaling pathway: K. Horikawa, et al.; FEBS Lett. 580, 3721 (2006), Abstract;
Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells: T. Shiraishi, et al.; Cancer Res. 65, 6364 (2005), Abstract;
Tunicamycin inhibits NMDA and AMPA receptor responses independently of N-glycosylation: K. Maruo, et al.; Brain Res. 977, 294 (2003), Abstract;
Tunicamycin inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells: A. Tordai, et al.; BBRC 206, 857 (1995), Abstract;
Role of N-glycosylation in the structure and function of the methotrexate membrane transporter from CCRF-CEM human lymphoblastic leukemia cells: L.H. Matherly & S.M. Angeles; Biochem. Pharmacol. 47, 1094 (1994), Abstract;
Isoprenoids and astroglial cell cycling: diminished mevalonate availability and inhibition of dolichol-linked glycoprotein synthesis arrest cycling through distinct mechanisms: T.J. Langan & M.C. Slater; J. Cell Physiol. 149, 284 (1991), Abstract;
Dolichol-linked glycoprotein synthesis in G1 is necessary for DNA synthesis in synchronized primary cultures of cerebral glia: S. Ishii & J.J. Volpe; J. Neurochem. 49, 1606 (1987), Abstract;
Relationship of the structure and biological activity of the natural homologues of tunicamycin: D. Duksin & W.C. Mahoney; J. Biol. Chem. 257, 3105 (1982), Abstract; Full Text
Isolation and structures of components of Tunicamycin: T. Ito, et al.; Agric. Biol. Chem. 44, 695 (1980),
Separation of tunicamycin homologues by reversed-phase high-performance liquid chromatography: W.C. Mahoney & D. Duksin; J. Chromatogr. 198, 506 (1980), Abstract;
Tunicamycin, a new antibiotic. I. Isolation and characterization of tunicamycin: A. Takatsuki, et al.; J. Antibiot. (Tokyo) 24, 215 (1971), Abstract;

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