A rare plant amino acid that reversibly blocks the cell cycle at G1-phase. Inhibits the hydroxylation of deoxyhypusine and thus inhibits eukaryote initiation factor 5-A (eIF5-A). Inhibitor of mammalian tyrosinase and dopamine β-hydroxylase. Also chelates iron via the kojic acid metal-binding domain. Arrests DNA synthesis by inhibiting deoxyribonucleotide metabolism.
Product Details
| Formula: | C8H10N2O4 |
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| MW: | 198.2 |
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| CAS: | 500-44-7 |
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| Purity: | ≥98% |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | Pink to brown powder. |
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| Solubility: | Soluble in 10% sodium bicarbonate (15mg/ml) |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Evaluation of hypoxia inducible factor targeting pharmacological drugs as antileishmanial agents: M.D. Pelegrini, et al.; Asian. Pac. J. Trop. Med.
9, 652 (2016),
Application(s): Cell culture,
Abstract;
Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism: D. M. Gilbert et al.; J. Biol. Chem.
270, 9597 (1995),
Abstract;
Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation: H. M. Hanauske-Abel et al.; Biochim. Biophys. Acta.
1221, 115 (1994),
Abstract;
A general protocol for evaluating the specific effects of DNA replication inhibitors: V. Levenson et al.; Nucleic. Acids. Res.
21, 3997 (1993),
Abstract;
Inhibition of two copper-containing enzymes, tyrosinase and dopamine beta-hydroxylase, by L-mimosine: H. Hashiguchi & H. Takahashi; Mo Pharmacol.
13, 362 (1977),
Abstract;
