Gingerol ([6]-gingerol), a pungent vanilloid isolated from ginger rhizomes (Zingiber officinale), is a novel and selective activator of skeletal and cardiac SR Ca2+-ATPase (EC50=4µM). It is a novel cardiotonic agent with antiplatelet activity. It induces apoptosis in HL-60 cells. Acts as an agonist at vanilloid receptors.
Product Details
| Formula: | C17H26O4 |
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| MW: | 294.4 |
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| CAS: | 23513-14-6 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White to pale yellow oily or waxy solid. |
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| MeltingPoint: | 31°C |
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| Solubility: | Soluble in 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Stromal Interaction Molecule 1 Rescues Store-Operated Calcium Entry and Protects NG115-401L Cells Against Cell Death Induced by Endoplasmic Reticulum and Mitochondrial Oxidative Stress: C. Zhang, et al.; Neurochem. Int.
97, 137 (2016),
Application(s): Cell culture,
Abstract;
Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin: S.O. Kim, et al.; Biofactors
21, 27 (2004),
Abstract;
Gingerols: a novel class of vanilloid receptor (VR1) agonists: V. N. Dedov, et al.; Br. J. Pharmacol.
137, 793 (2002),
Abstract;
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Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol: E. Lee, et al. ; Cancer Lett.
134, 163 (1998),
Abstract;
Antiplatelet effect of gingerol isolated from Zingiber officinale: J. H. Guh, et al. ; J. Pharm. Pharmacol.
47, 329 (1995),
Abstract;
Gingerol, a novel cardiotonic agent, activates the Ca2+-pumping ATPase in skeletal and cardiac sarcoplasmic reticulum: M. Kobayashi, et al.; Biochim. Biophys. Acta
903, 96 (1987),
Abstract;
