Replaces Prod. #: ALX-350-023
Mycotoxin. Cell permeable. Induces the release of intracellular stored Ca2+ without increasing IP3 levels via inhibition of endoplasmic reticulum Ca2+-ATPase. Highly specific inhibitor of Ca2+-ATPase of sarcoplasmic reticulum, completely inhibiting the enzyme at 6-8 nmol/mg protein (at 0.5-2.0µM ATP).
Product Details
| Alternative Name: | CPA |
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| Formula: | C20H20N2O3 |
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| MW: | 336.4 |
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| CAS: | 18172-33-3 |
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| RTECS: | UY8587000 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white to faint yellow solid. |
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| Solubility: | Soluble in DMSO (20mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Vanillin Induces Relaxation in Rat Mesenteric Resistance Arteries by Inhibiting Extracellular Ca2+ Influx: S. Choi, et al.; Molecules
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Abstract;
DPB162-AE, an inhibitor of store-operated Ca2+ entry, can deplete the endoplasmic reticulum Ca2+ store: M. Bittremieux, et al.; Cell Calcium
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Application(s): Treatment of pancreatic acinar cells,
Abstract;
Stromal Interaction Molecule 1 Rescues Store-Operated Calcium Entry and Protects NG115-401L Cells Against Cell Death Induced by Endoplasmic Reticulum and Mitochondrial Oxidative Stress: C. Zhang, et al.; Neurochem. Int.
97, 137 (2016),
Application(s): Cell culture,
Abstract;
Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line: S. Park, et al.; Korean J. Physiol. Pharmacol.
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Application(s): Cell Culture,
Abstract;
Full Text
Cyclopiazonic acid reduces the coupling factor of the Ca2+-ATPase acting on Ca2+ binding: F. Martinez-Azorin; FEBS Lett.
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Abstract;
Recent advances in analytical methodology for cyclopiazonic acid: J.W. Dorner; Adv. Exp. Med. Biol.
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Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells: N. Demaurex, et al.; J. Biol. Chem.
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Full Text
Cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca(2+)- pump, reduces Ca(2+)-dependent K+ currents in guinea-pig smooth muscle cells: M. Suzuki, et al.; Br. J. Pharmacol.
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Abstract;
Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle: Y. Uyama, et al.; Br. J. Pharmacol.
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Acetylcholine Ca2+ stores refilling directly involves a dihydropyridine- sensitive channel in dog trachea: J.P. Bourreau, et al.; Am. J. Physiol.
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Abstract;
Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di- (tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes: M.J. Mason, et al.; J. Biol. Chem.
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Full Text
Discrimination of Ca(2+)-ATPase activity of the sarcoplasmic reticulum from actomyosin-type ATPase activity of myofibrils in skinned mammalian skeletal muscle fibres: distinct effects of cyclopiazonic acid on the two ATPase activities: N. Kurebayashi & Y. Ogawa; J. Muscle Res. Cell Motility
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Abstract;
Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum: N.W. Seidler, et al.; J. Biol. Chem.
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Abstract;
Full Text
Cyclopiazonic acid inhibition of the Ca2+-transport ATPase in rat skeletal muscle sarcoplasmic reticulum vesicles: D.E. Goeger, et al.; Biochem. Pharmacol.
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