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United States 

BAPTA, free acid

Cell impermeable calcium chelator
BML-CA412-0100 100 mg 86.00 USD
BML-CA412-0500 500 mg 338.00 USD
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Replaces Prod. #: ALX-450-013

BAPTA is a Ca2+ chelator with 105-fold greater affinity for Ca2+ than for Mg2+. BAPTA, free acid is not cell permeable and is therefore useful as an extracellular calcium sponge.

Product Details

Alternative Name:1,2-bis-(o-Aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid
Purity:≥97% (HPLC)
Appearance:White solid.
Solubility:Soluble in DMSO (25mg/ml) and dimethylformamide (25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling:Protect from moisture.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Chelation of intracellular Ca2+ inhibits murine keratinocyte differentiation in vitro: L. Li et al.; J. Cell. Physiol. 163, 105 (1995), Abstract;
Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro: M. Tymianski et al.; J. Neurophysiol. 72, 1973 (1994), Abstract;
Calcium-independent increase of transmitter release at frog end-plate by trinitrobenzene sulphonic acid: H. Kijima & N. Tanabe; J. Physiol. 403, 135 (1988), Abstract;
Transmitter release at frog end-plate loaded with a Ca2+-chelator, BAPTA: hypertonicity and erythrosin B augment the release independently of internal Ca2+: N. Tanabe & H. Kijima ; Neurosci. Lett. 92, 52 (1988), Abstract;
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures: R.Y. Tsien et al.; Biochemistry 19, 2396 (1980), Abstract;