Replaces Prod. #: ALX-450-013
BAPTA is a Ca2+ chelator with 105-fold greater affinity for Ca2+ than for Mg2+. BAPTA, free acid is not cell permeable and is therefore useful as an extracellular calcium sponge.
Product Details
| Alternative Name: | 1,2-bis-(o-Aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid |
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| Formula: | C22H24N2O10 |
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| MW: | 476.4 |
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| CAS: | 85233-19-8 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) and dimethylformamide (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Handling: | Protect from moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Chelation of intracellular Ca2+ inhibits murine keratinocyte differentiation in vitro: L. Li et al.; J. Cell. Physiol.
163, 105 (1995),
Abstract;
Properties of neuroprotective cell-permeant Ca2+ chelators: effects on [Ca2+]i and glutamate neurotoxicity in vitro: M. Tymianski et al.; J. Neurophysiol.
72, 1973 (1994),
Abstract;
Calcium-independent increase of transmitter release at frog end-plate by trinitrobenzene sulphonic acid: H. Kijima & N. Tanabe; J. Physiol.
403, 135 (1988),
Abstract;
Transmitter release at frog end-plate loaded with a Ca2+-chelator, BAPTA: hypertonicity and erythrosin B augment the release independently of internal Ca2+: N. Tanabe & H. Kijima ; Neurosci. Lett.
92, 52 (1988),
Abstract;
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures: R.Y. Tsien et al.; Biochemistry
19, 2396 (1980),
Abstract;
