Replaces Prod. #: ALX-450-014
BAPTA is a Ca2+ chelator with 105-fold greater affinity for Ca2+ than for Mg2+. BAPTA-AM is a cell-permeable derivative which is widely used as an intracellular calcium sponge. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.
Product Details
Alternative Name: | 1,2-bis-(o-Aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl ester |
|
Formula: | C34H40N2O18 |
|
MW: | 764.7 |
|
CAS: | 126150-97-8 |
|
Purity: | ≥90% (HPLC) |
|
Identity: | Determined by NMR. |
|
Appearance: | White to off-white powder. |
|
Solubility: | Soluble in DMSO (25mg/ml), dimethyl formamide (25mg/ml) or 100% ethanol (5mg/ml, warm) |
|
Shipping: | Ambient |
|
Long Term Storage: | -20°C |
|
Handling: | Protect from light. |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over
Product Literature References
SARS-CoV-2 causes secretory diarrhea with an enterotoxin-like mechanism, which is reduced by diosmectite: M. Poeta, et al.; Heliyon
8, e10246 (2022),
Abstract;
Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation: N.N.T. Nguyen, et al.; Sci. Rep.
8, 15486 (2018),
Abstract;
Full Text
Cadmium overkill: autophagy, apoptosis and necrosis signalling in endothelial cells exposed to cadmium: B. Messner, et al.; Cell Mol. Life Sci.
73, 1699 (2016),
Application(s): Sensitive intracellular Ca2+ chelator,
Abstract;
Full Text
Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl: D. Manganaro, et al.; Biochim. Biophys. Acta
1853, 1879 (2015),
Application(s): Cell Culture,
Abstract;
Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation: C.S. Breton, et al.; Biochimie
116, 141 (2015),
Application(s): Cell Culture,
Abstract;
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells: T. Bouschet et al.; J. Biol. Chem.
278, 4778 (2003),
Abstract;
Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin: S. Jiang et al.; Exp. Cell Res.
212, 84 (1994),
Abstract;
BAPTA induces a decrease of intracellular free calcium and a translocation and inactivation of protein kinase C in macrophages: P. Dieter et al.; Biol. Chem. Hoppe Seyler
374, 171 (1993),
Abstract;
Intracellular calcium chelator, BAPTA-AM, prevents cocaine-induced ventricular fibrillation: G.E. Billman ; Am. J. Physiol.
265, H1529 (1993),
Abstract;
Role of calcium ion in induction of apoptosis by etoposide in human leukemia HL-60 cells: A. Yoshida et al.; Biochem. Biophys. Res. Commun.
196, 927 (1993),
Abstract;
Cytosolic calcium as a second messenger for collagen-induced plsatelet responses: J.B. Smith et al.; Biochem. J.
288 , 925 (1992),
Abstract;
The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA: S.M. Harrison & D.M. Bers; Biochim. Biophys. Acta
925, 133 (1987),
Abstract;
Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator: R.Y. Tsien et al.; Nature
298, 478 (1982),
Abstract;