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BAPTA-AM

PKC activator



BML-CA411-0025	25 mg	251.00 USD
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Replaces Prod. #: ALX-450-014

BAPTA is a Ca²⁺ chelator with 105-fold greater affinity for Ca²⁺ than for Mg²⁺. BAPTA-AM is a cell-permeable derivative which is widely used as an intracellular calcium sponge. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.

Product Details

Alternative Name:	1,2-bis-(o-Aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl ester

Formula:	C₃₄H₄₀N₂O₁₈

MW:	764.7

CAS:	126150-97-8

Purity:	≥90% (HPLC)

Identity:	Determined by NMR.

Appearance:	White to off-white powder.

Solubility:	Soluble in DMSO (25mg/ml), dimethyl formamide (25mg/ml) or 100% ethanol (5mg/ml, warm)

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

SARS-CoV-2 causes secretory diarrhea with an enterotoxin-like mechanism, which is reduced by diosmectite: M. Poeta, et al.; Heliyon 8, e10246 (2022), Abstract;

Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation: N.N.T. Nguyen, et al.; Sci. Rep. 8, 15486 (2018), Abstract; Full Text

Cadmium overkill: autophagy, apoptosis and necrosis signalling in endothelial cells exposed to cadmium: B. Messner, et al.; Cell Mol. Life Sci. 73, 1699 (2016), Application(s): Sensitive intracellular Ca2+ chelator, Abstract; Full Text

Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl: D. Manganaro, et al.; Biochim. Biophys. Acta 1853, 1879 (2015), Application(s): Cell Culture, Abstract;

Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation: C.S. Breton, et al.; Biochimie 116, 141 (2015), Application(s): Cell Culture, Abstract;

Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells: T. Bouschet et al.; J. Biol. Chem. 278, 4778 (2003), Abstract;

Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin: S. Jiang et al.; Exp. Cell Res. 212, 84 (1994), Abstract;

BAPTA induces a decrease of intracellular free calcium and a translocation and inactivation of protein kinase C in macrophages: P. Dieter et al.; Biol. Chem. Hoppe Seyler 374, 171 (1993), Abstract;

Intracellular calcium chelator, BAPTA-AM, prevents cocaine-induced ventricular fibrillation: G.E. Billman ; Am. J. Physiol. 265, H1529 (1993), Abstract;

Role of calcium ion in induction of apoptosis by etoposide in human leukemia HL-60 cells: A. Yoshida et al.; Biochem. Biophys. Res. Commun. 196, 927 (1993), Abstract;

Cytosolic calcium as a second messenger for collagen-induced plsatelet responses: J.B. Smith et al.; Biochem. J. 288 , 925 (1992), Abstract;

The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA: S.M. Harrison & D.M. Bers; Biochim. Biophys. Acta 925, 133 (1987), Abstract;

Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator: R.Y. Tsien et al.; Nature 298, 478 (1982), Abstract;