Replaces Prod. #: ALX-550-213
A potent, direct acting, voltage-sensitive Ca2+ channel (L-type) activator. It exerts positive inotropic, vasoconstrictive and positive chronotropic activity (in vitro and in vivo) in a concentration range from 10-9 to 10-7 M.
Product Details
| Formula: | C16H15F3N2O4 |
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| MW: | 356.3 |
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| CAS: | 71145-03-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in 100% ethanol (20mg/ml), DMSO (20mg/ml) or methanol. Slightly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at 0-4°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Calcium channel ligands: D.J. Triggle & R.A. Janis; Annu. Rev. Pharmacol. Toxicol.
27, 347 (1987),
Abstract;
[3H]BAY K 8644, a 1,4-dihydropyridine Ca++ channel activator: characteristics of binding to high and low affinity sites in cardiac membranes: J.G. Sarmiento et al.; J. Pharmacol. Exp. Ther.
241, 140 (1987),
Abstract;
A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent: G. Thomas et al.; Circ. Res.
56, 87 (1985),
Abstract;
Effects of Bay k 8644, a dihydropyridine analog, on [3H]nitrendipine binding to canine cardiac sarcolemma and the relationship to a positive inotropic effect: P.L. Vaghy et al.; Circ. Res.
55, 549 (1984),
Abstract;
