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Calmodulin inhibitor
BML-CA320-0050 50 mg 129.00 USD
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Replaces Prod. #: ALX-270-153

Binds to calmodulin, inhibiting Ca2+-calmodulin-regulated enzyme activity. It inhibits the Ca2+/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC50=25 µM). Cell permeable.

Product Details

Alternative Name:N-(6-Aminohexyl)-5-chloro-1-naphtalene-sulfonamide . HCl
Formula:C16H21ClN2O2S . HCl
Purity:≥98% (TLC)
Appearance:White to off-white solid.
Solubility:Soluble in water (warm), methanol, 100% ethanol (10mg/ml) (warm), DMSO (25mg/ml), dimethyl formamide or ethylene glycol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Interleukin-1β processing is dependent upon a calcium-mediated interaction with calmodulin: J.S. Ainscough, et al.; J. Biol. Chem. 290, 31151 (2015), Application(s): Cell culture, Abstract; Full Text
N-Methyl-D-Aspartate Receptor-Dependent Denitrosylation of Neuronal Nitric Oxide Synthase Increase the Enzyme Activity: Z.W. Qu, et al.; PLoS One 7, e52788 (2012), Abstract; Full Text
Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase.: H. Itoh & H. Hidaka; J. Biochem. 96, 1721 (1984), Abstract;
Calmodulin antagonists' binding sites on calmodulin.: T. Tanaka, et al.; Pharmacology 26, 249 (1983), Abstract;
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives.: H. Hidaka, et al.; Mol. Pharmacol. 20, 571 (1981), Abstract;
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.: H. Hidaka, et al.; PNAS 78, 4354 (1981), Abstract; Full Text