Replaces Prod. #: ALX-270-153
Binds to calmodulin, inhibiting Ca2+-calmodulin-regulated enzyme activity. It inhibits the Ca2+/calmodulin-induced activation of myosin light chain kinase in a concentration dependent manner (IC50=25 µM). Cell permeable.
Product Details
| Alternative Name: | N-(6-Aminohexyl)-5-chloro-1-naphtalene-sulfonamide . HCl |
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| Formula: | C16H21ClN2O2S . HCl |
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| MW: | 377.3 |
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| CAS: | 61714-27-0 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (warm), methanol, 100% ethanol (10mg/ml) (warm), DMSO (25mg/ml), dimethyl formamide or ethylene glycol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Interleukin-1β processing is dependent upon a calcium-mediated interaction with calmodulin: J.S. Ainscough, et al.; J. Biol. Chem.
290, 31151 (2015),
Application(s): Cell culture,
Abstract;
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N-Methyl-D-Aspartate Receptor-Dependent Denitrosylation of Neuronal Nitric Oxide Synthase Increase the Enzyme Activity: Z.W. Qu, et al.; PLoS One
7, e52788 (2012),
Abstract;
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Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase.: H. Itoh & H. Hidaka; J. Biochem.
96, 1721 (1984),
Abstract;
Calmodulin antagonists' binding sites on calmodulin.: T. Tanaka, et al.; Pharmacology
26, 249 (1983),
Abstract;
Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives.: H. Hidaka, et al.; Mol. Pharmacol.
20, 571 (1981),
Abstract;
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.: H. Hidaka, et al.; PNAS
78, 4354 (1981),
Abstract;
Full Text
