Gabapentin is a GABA analog which does not act at GABA receptors but which inhibits L-type calcium channels via binding to the α2-δ subunit and neuropathic pain relieving actions. Ligands acting at the α2-δ subunit lead to anticonvulsant, anxiolytic and neuropathic pain-relieving actions.
Product Details
| Formula: | C9H17NO2 |
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| MW: | 171.2 |
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| CAS: | 60142-96-3 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The mechanism of action of gabapentin in neuropathic pain: J. K. Baillie, et al.; Curr. Opin. Investig. Drugs
7, 33 (2006),
Abstract;
Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein: J. B. Schwartz, et al. ; J. Med. Chem.
48, 3026 (2005),
Abstract;
Mechanism of action of alpha2delta ligands: voltage sensitive calcium channel (VSCC) modulators: S. M. Stahl, et al.; J. Clin. Psychiatry
65, 1033 (2004),
Abstract;
