AMG-9810 is an antagonist of capsaicin activation of TRPV1 (IC50=24.5 nM) as well as activation by acid, heat, and endogenous ligands.
Product Details
| Formula: | C21H23NO3 |
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| MW: | 337.4 |
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| CAS: | 545395-94-6 |
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| Purity: | ≥98% |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml); ethanol (20mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties: N. R. Gavva, et al.; J. Pharmacol. Exp. Ther.
313, 474 (2005),
Abstract;
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