Replaces Prod. #: ALX-550-297
A novel, selective inhibitor of receptor-mediated calcium entry. It inhibits receptor-mediated calcium entry in stimulated platelets (IC50=8-12µM) neutrophils and endothelial cells at concentrations which do not affect internal Ca2+ release. Note, in some cells SK&F 96365 can activate a novel Ca2+ entry pathway. Blocks TRPC3 and TRPC6 activation. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.
Product Details
| Alternative Name: | 1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole . HCl, SKF-96365 . hydrochloride |
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| Formula: | C22H26N2O3 . HCl |
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| MW: | 402.9 |
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| CAS: | 130495-35-1 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| MeltingPoint: | 117-119°C |
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| Solubility: | Soluble in water (30mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Optopharmacological control of TRPC channels by coumarin-caged lipids is associated with a phototoxic membrane effect: O. Tiapko, et al.; Sci. China Life Sci.
59, 802 (2016),
Application(s): Measurement of intracellular Ca2+ signaling,
Abstract;
Dual effects of SK&F 96365 in human leukemic HL-60 cells. Inhibition of calcium entry and activation of a novel cation influx pathway: Y.M. Leung, et al.; Biochem. Pharmacol.
51, 605 (1996),
Abstract;
Vectorial Ca2+ flux from the extracellular space to the endoplasmic reticulum via a restricted cytoplasmic compartment regulates inositol 1,4,5-trisphosphate-stimulated Ca2+ release from internal stores in vascular endothelial cells: O.A. Cabello, et al.; Biochem. J.
295, 357 (1993),
Abstract;
SK&F 96365 inhibits histamine-induced formation of endothelium-derived relaxing factor in human endothelial cells: W.F. Graier, et al.; Biochem. Biophys. Res. Commun.
186, 1539 (1992),
Abstract;
Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase: L.M. Blayney, et al.; Biochem. J.
273, 803 (1991),
Abstract;
SK&F 96365, a receptor-mediated calcium entry inhibitor, inhibits calcium responses to endothelin-1 in NG108-15 cells: J. Chan, et al.; Biochem. Biophys. Res. Commun.
177, 1141 (1991),
Abstract;
Receptor-mediated calcium influx in PC12 cells. ATP and bradykinin activate two independent pathways: C. Fasolato, et al.; J. Biol. Chem.
265, 20351 (1990),
Abstract;
SK&F 96365, a novel inhibitor of receptor-mediated calcium entry: J.E. Merritt, et al.; Biochem. J.
271, 515 (1990),
Abstract;
