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Niguldipine . HCl

Ca2+ channel blocker
BML-CA216-0010 10 mg 109.00 USD
BML-CA216-0050 50 mg 431.00 USD
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Replaces Prod. #: ALX-550-274

A classic L-type Ca2+ channel blocker (IC50=75nM) which can also inhibit T-type Ca2+ channels (IC50=244nM). It is a novel inhibitor of drug transport by p-glycoprotein (both stereoisomers are equipotent at inhibition of p-glycoprotein).

Product Details

Alternative Name:(±)-Niguldipine . hydrochloride, (±)-1,4-Dihydro-2,6-dimethyl-4-(3’-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4’,4’-diphenyl-1’-piperidinyl)propylmethyl ester . HCl
Formula:C36H39N3O6 . HCl
Purity:≥95% (TLC)
Appearance:Yellow crystalline solid.
Solubility:Soluble in DMSO or methanol.
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Different potencies of dihydropyridine derivatives in blocking T-type but not L-type Ca2+ channels in neuroblastoma-glioma hybrid cells: W. Stengel, et al.; Eur. J. Pharmacol. 342, 339 (1998), Abstract;
Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein: V. Hollt, et al.; Biochem. Pharmacol. 43, 2601 (1992), Abstract;
Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices: J.P. Robinson & D.A. Kendall; Br. J. Pharmacol. 100, 3 (1990), Abstract;
Stereoselective binding of niguldipine enantiomers to alpha 1A-adrenoceptors labeled with [3H]5-methyl-urapidil: I. Graziadei, et al.; Eur. J. Pharmacol. 172, 329 (1989), Abstract;

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