Replaces Prod. #: ALX-550-274
A classic L-type Ca2+ channel blocker (IC50=75nM) which can also inhibit T-type Ca2+ channels (IC50=244nM). It is a novel inhibitor of drug transport by p-glycoprotein (both stereoisomers are equipotent at inhibition of p-glycoprotein).
Product Details
| Alternative Name: | (±)-Niguldipine . hydrochloride, (±)-1,4-Dihydro-2,6-dimethyl-4-(3’-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4’,4’-diphenyl-1’-piperidinyl)propylmethyl ester . HCl |
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| Formula: | C36H39N3O6 . HCl |
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| MW: | 646.2 |
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| CAS: | 119934-51-9 |
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| Purity: | ≥95% (TLC) |
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| Appearance: | Yellow crystalline solid. |
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| Solubility: | Soluble in DMSO or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Different potencies of dihydropyridine derivatives in blocking T-type but not L-type Ca2+ channels in neuroblastoma-glioma hybrid cells: W. Stengel, et al.; Eur. J. Pharmacol.
342, 339 (1998),
Abstract;
Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein: V. Hollt, et al.; Biochem. Pharmacol.
43, 2601 (1992),
Abstract;
Niguldipine discriminates between alpha 1-adrenoceptor-mediated second messenger responses in rat cerebral cortex slices: J.P. Robinson & D.A. Kendall; Br. J. Pharmacol.
100, 3 (1990),
Abstract;
Stereoselective binding of niguldipine enantiomers to alpha 1A-adrenoceptors labeled with [3H]5-methyl-urapidil: I. Graziadei, et al.; Eur. J. Pharmacol.
172, 329 (1989),
Abstract;
