Potent and selective L-type calcium channel blocker. A clinically useful antihypertensive agent which has anti-atherosclerotic effects and improves endothelium-mediated NO-dependent vasodilation. Displays neuroprotective activity in a rat model of focal ischemia.
Product Details
| Formula: | C19H21N3O5 |
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| MW: | 371.4 |
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| CAS: | 75695-93-1 |
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| RTECS: | U57968632 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (25 mg/ml) or 100% ethanol (15 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. Store under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia: C. Bracht, et al.; J. Hyperten.
19, 899 (2001),
Abstract;
Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia: S. Chandra, et al.; Pharmacology
58, 292 (1999),
Abstract;
