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2',4'-Dichlorobenzamil . HCl

Ca2+ channel blocker
BML-CA204-0005 5 mg 108.00 USD
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Inhibits cyclic nucleotide-gated Ca2+ channels (IC50=38-50µM). Inhibits plasmalemmal Na+/Ca2+ and Na+/H+ exchange (IC50=10µM). Blocks caffeine-induced current (by blocking Na+/Ca2+ exchange) at 50-100µM. Nonselective cation channel blocker (25µM).

Product Details

Formula:C13H12Cl3N7O . HCl
Purity:≥95% (HPLC)
Appearance:Yellow solid.
Solubility:Soluble in DMSO (25 mg/ml), Ethanol (25 mg/ml) or DMF (25 mg/ml).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Store, as supplied, at -20°C for up to one year. Store solutions at -20°C for up to three months.
Regulatory Status:RUO - Research Use Only
BML-CA204 structure
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BML-CA204 structure

Product Literature References

Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells: Y. Cay, et al.; Arterioscler. Thromb. Vasc. Biol. 31, 616 (2011), Abstract; Full Text
Electrogenic Na(+)/Ca(2+) exchange A novel amplification step in squid olfactory transduction: J. P. Danaceau & M. T. Lucero; J. Gen. Physiol. 115, 759 (2000), Abstract; Full Text
Histamine-induced Ca2+ oscillations in a human endothelial cell line depend on transmembrane ion flux, ryanodine receptors and endoplasmic reticulum Ca2+-ATPase: J. Paltauf-Doburzynska, et al.; J. Physiol. 524, 701 (2000), Abstract; Full Text
Characterization of a palytoxin-induced non-selective cation channel in mouse megakaryocytes: K. Ichida, et al.; Jpn. J. Pharmacol. 81, 200 (1999), Abstract;
Expression of cyclic nucleotide-gated cation channels in airway epithelial cells: W. Xu, et al.; J. Membr. Biol. 171, 117 (1999), Abstract;
Effects of 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB8) on rat atrial muscle: B. J. Northover, et al.; Biochem. Pharmacol. 44, 425 (1992), Abstract;

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