Inhibits cyclic nucleotide-gated Ca2+ channels (IC50=38-50µM). Inhibits plasmalemmal Na+/Ca2+ and Na+/H+ exchange (IC50=10µM). Blocks caffeine-induced current (by blocking Na+/Ca2+ exchange) at 50-100µM. Nonselective cation channel blocker (25µM).
Product Details
| Formula: | C13H12Cl3N7O . HCl |
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| MW: | 425.1 |
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| CAS: | 2088-58-6 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (25 mg/ml), Ethanol (25 mg/ml) or DMF (25 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at -20°C for up to one year. Store solutions at -20°C for up to three months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells: Y. Cay, et al.; Arterioscler. Thromb. Vasc. Biol.
31, 616 (2011),
Abstract;
Full Text
Electrogenic Na(+)/Ca(2+) exchange A novel amplification step in squid olfactory transduction: J. P. Danaceau & M. T. Lucero; J. Gen. Physiol.
115, 759 (2000),
Abstract;
Full Text
Histamine-induced Ca2+ oscillations in a human endothelial cell line depend on transmembrane ion flux, ryanodine receptors and endoplasmic reticulum Ca2+-ATPase: J. Paltauf-Doburzynska, et al.; J. Physiol.
524, 701 (2000),
Abstract;
Full Text
Characterization of a palytoxin-induced non-selective cation channel in mouse megakaryocytes: K. Ichida, et al.; Jpn. J. Pharmacol.
81, 200 (1999),
Abstract;
Expression of cyclic nucleotide-gated cation channels in airway epithelial cells: W. Xu, et al.; J. Membr. Biol.
171, 117 (1999),
Abstract;
Effects of 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB8) on rat atrial muscle: B. J. Northover, et al.; Biochem. Pharmacol.
44, 425 (1992),
Abstract;
