Inhibits cyclic nucleotide-gated Ca2+ channels (IC50=38-50µM). Inhibits plasmalemmal Na+/Ca2+ and Na+/H+ exchange (IC50=10µM). Blocks caffeine-induced current (by blocking Na+/Ca2+ exchange) at 50-100µM. Nonselective cation channel blocker (25µM).
Product Details
| Formula: | C13H12Cl3N7O . HCl |
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| MW: | 425.1 |
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| CAS: | 2088-58-6 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (25 mg/ml), Ethanol (25 mg/ml) or DMF (25 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at -20°C for up to one year. Store solutions at -20°C for up to three months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Effects of 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB8) on rat atrial muscle: B. J. Northover, et al.; Biochem. Pharmacol.
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