Amlodipine is a third generation L-type calcium channel blocker with a unique spectrum of actions, over and above its antihypertensive activity which include stimulation of NO synthase, inhibition of monocyte-endothelial adhesion, inhibition of oxidative stress and sustained duration of action.
Product Details
| Formula: | C20H25ClN2O5 |
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| MW: | 408.9 |
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| CAS: | 88150-42-9 |
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| Purity: | ≥98% (Assay) |
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| Appearance: | Almost white crystal powder |
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| Solubility: | Soluble in methanol, DMSO (25mg/ml), 100% ethanol (25mg/ml), dimethyl formamide (25mg/ml) or chloroform. |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A calcium channel blocker activates both ecto-5(')-nucleotidase and NO synthase in HUVEC: Y. Asano, et al.; Biochem. Biophys. Res. Commun.
311, 625 (2003),
Abstract;
Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction: T. Yu, et al.; Hypertension
42, 329 (2003),
Abstract;
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Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine: R. P. Mason, et al.; Arterioscler. Thromb. Vasc. Biol.
23, 2155 (2003),
Abstract;
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A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects: S. Ueda, et al.; Br. J. Clin. Pharmacol.
36, 561 (1993),
Abstract;
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