(±)2-Acetyl-Anatoxin is an alkaloidal toxin produced by the filamentous freshwater cyanophyte Anabaena flos-aquae. This compound is the synthetic version.
Product Details
| Formula: | C10H15NO . C4H4O4 |
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| MW: | 281.3 |
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| CAS: | 1219922-30-1 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (14mg/ml). |
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| Application Notes: | (±)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. At low concentrations (20-200nM) it acts as an agonist. At higher concentrations (>800nM), it blocks the AChR ion channel, desensitizes the receptor and blocks neuromuscular transmission. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Are We Underestimating Benthic Cyanotoxins? Extensive Sampling Results from Spain: E. A. Cantoral Uriza, et al.; Toxins (Basel)
9, 385 (2017),
Abstract;
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Cyanotoxins at low doses induce apoptosis and inflammatory effects in murine brain cells: potential implications for neurodegenerative diseases: L. Takser, et al.; Toxicol. Rep.
3, 180 (2016),
Application(s): Cell culture,
Abstract;
(+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors: P. Thomas, et al.; J. Neurochem.
60, 2308 (1993),
Abstract;
Activation and blockade of the acetylcholine receptor-ion channel by the agonists (+)-anatoxin-a, the N-methyl derivative and the enantiomer: P. Kofuji, et al.; J. Pharmacol. Exp. Ther.
252, 517 (1990),
Abstract;
Molecular mechanisms of the potent and stereospecific nicotinic receptor agonist (+)-anatoxin-a: K. L. Swanson, et al.; Mol. Pharmacol.
29, 250 (1986),
Abstract;
