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(+/-) Anatoxin

Nicotinic acetylcholine receptor ligand
BML-C118-0001 1 mg 281.00 USD
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(±)2-Acetyl-Anatoxin is an alkaloidal toxin produced by the filamentous freshwater cyanophyte Anabaena flos-aquae.  This compound is the synthetic version.

Product Details

Formula:C10H15NO . C4H4O4
Purity:≥96% (HPLC)
Appearance:Light brown solid.
Solubility:Soluble in water (14mg/ml).
Application Notes:(±)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. At low concentrations (20-200nM) it acts as an agonist. At higher concentrations (>800nM), it blocks the AChR ion channel, desensitizes the receptor and blocks neuromuscular transmission.
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month
Regulatory Status:RUO - Research Use Only
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Product Literature References

Multiclass cyanotoxin analysis in reservoir waters: Tandem solid-phase extraction followed by zwitterionic hydrophilic interaction liquid chromatography-mass spectrometry: M.M. Aparicio-Muriana, et al.; Talanta 237, 122929 (2022), Abstract;
Are We Underestimating Benthic Cyanotoxins? Extensive Sampling Results from Spain: E. A. Cantoral Uriza, et al.; Toxins (Basel) 9, 385 (2017), Abstract; Full Text
Cyanotoxins at low doses induce apoptosis and inflammatory effects in murine brain cells: potential implications for neurodegenerative diseases: L. Takser, et al.; Toxicol. Rep. 3, 180 (2016), Application(s): Cell culture, Abstract;
(+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors: P. Thomas, et al.; J. Neurochem. 60, 2308 (1993), Abstract;
Activation and blockade of the acetylcholine receptor-ion channel by the agonists (+)-anatoxin-a, the N-methyl derivative and the enantiomer: P. Kofuji, et al.; J. Pharmacol. Exp. Ther. 252, 517 (1990), Abstract;
Molecular mechanisms of the potent and stereospecific nicotinic receptor agonist (+)-anatoxin-a: K. L. Swanson, et al.; Mol. Pharmacol. 29, 250 (1986), Abstract;

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