A substrate for the trypsin-like activity of the 20S proteasome.
Product Details
| Alternative Name: | Bz-VGR-AMC |
| |
| Sequence: | Bz-VGR-AMC, Fluorogenic Substrate |
| |
| Formula: | C30H37N7O6 . TFA |
| |
| MW: | 591.67 |
| |
| CAS: | 87779-49-5 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Appearance: | White powder. |
| |
| Solubility: | Soluble in methanol or DMSO. |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
Short-term exposure to an obesogenic diet causes dynamic dysregulation of proteasome-mediated protein degradation in the hypothalamus of female rats: T. McFadden, et al.; Nutr. Neurosci.
13, 1 (2022),
Abstract;
Comprehensive Analysis of Proteasomal Complexes in Mouse Brain Regions Detects ENO2 as a Potential Partner of the Proteasome in the Striatum: N. Esfahanian, et al.; Cell. Mol. Neurobiol. (2021),
Abstract;
Males and Females Differ in the Subcellular and Brain Region Dependent Regulation of Proteasome Activity by CaMKII and Protein Kinase A: R.K. Devulapalli, et al.; Neuroscience
418, 1 (2019),
Abstract;
Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)-Mixed Lineage Kinase Domain-Like Protein (MLKL)-Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers: H.M. Ni, et al.; Am. J. Pathol.
189, 1363 (2019),
Abstract;
Skeletal Muscle Denervation Investigations: Selecting an Experimental Control Wisely: H. Liu, et al.; Am. J. Physiol. Cell Physiol.
316, C456 (2019),
Abstract;
Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Model: N.K. Lee, et al.; Sci. Rep.
7, 39340 (2017),
Abstract;
Full Text
Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases: L. Lauinger, et al.; Nat. Chem. Biol.
13, 709 (2017),
Abstract;
Full Text
Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome: H.M. Lee, et al.; PLoS One
11, e0166831 (2016),
Abstract;
Full Text
Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease: R. Velazquez, et al.; Mol. Neurodegener.
11, 52 (2016),
Application(s): Proteasome activity, brain homogenate,
Abstract;
Full Text
Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells: H. Jiang, et al.; Cell Death Dis.
4, e761 (2013),
Application(s): Fluorogenic substrate for kinetics assay of 20S proteasome,
Abstract;
Full Text
