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BML-BW9375-0005 5 mg 142.00 USD
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A substrate for the trypsin-like activity of the 20S proteasome.

Product Details

Alternative Name:Bz-VGR-AMC
Sequence:Bz-VGR-AMC, Fluorogenic Substrate
Formula:C30H37N7O6 . TFA
Purity:≥98% (HPLC)
Appearance:White powder.
Solubility:Soluble in methanol or DMSO.
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Comprehensive Analysis of Proteasomal Complexes in Mouse Brain Regions Detects ENO2 as a Potential Partner of the Proteasome in the Striatum: N. Esfahanian, et al.; Cell. Mol. Neurobiol. 42, 2305 (2022), Abstract;
Short-term exposure to an obesogenic diet causes dynamic dysregulation of proteasome-mediated protein degradation in the hypothalamus of female rats: T. McFadden, et al.; Nutr. Neurosci. 13, 1 (2022), Abstract;
Males and Females Differ in the Subcellular and Brain Region Dependent Regulation of Proteasome Activity by CaMKII and Protein Kinase A: R.K. Devulapalli, et al.; Neuroscience 418, 1 (2019), Abstract;
Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)-Mixed Lineage Kinase Domain-Like Protein (MLKL)-Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers: H.M. Ni, et al.; Am. J. Pathol. 189, 1363 (2019), Abstract;
Skeletal Muscle Denervation Investigations: Selecting an Experimental Control Wisely: H. Liu, et al.; Am. J. Physiol. Cell Physiol. 316, C456 (2019), Abstract;
Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Model: N.K. Lee, et al.; Sci. Rep. 7, 39340 (2017), Abstract; Full Text
Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases: L. Lauinger, et al.; Nat. Chem. Biol. 13, 709 (2017), Abstract; Full Text
Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome: H.M. Lee, et al.; PLoS One 11, e0166831 (2016), Abstract; Full Text
Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease: R. Velazquez, et al.; Mol. Neurodegener. 11, 52 (2016), Application(s): Proteasome activity, brain homogenate, Abstract; Full Text
Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells: H. Jiang, et al.; Cell Death Dis. 4, e761 (2013), Application(s): Fluorogenic substrate for kinetics assay of 20S proteasome, Abstract; Full Text

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