Highly specific substrate for the caspase-like peptidic activity of the 20S proteasome.
Product Details
| Alternative Name: | Ac-GPLD-AMC |
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| Sequence: | Ac-GPLD-AMC, Fluorogenic Substrate |
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| Formula: | C29H37N5O9 |
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| MW: | 599.64 |
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| Source: | Synthetic. |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in 20% aqueous acetic acid (1mg/ml). |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store solutions at or below -20°C for up to 3 months |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Model: N.K. Lee, et al.; Sci. Rep.
7, 39340 (2017),
Abstract;
Full Text
Proteasome properties of hemocytes differ between the whiteleg shrimp Penaeus vannamei and the brown shrimp Crangon crangon (Crustacea, Decapoda): S. Gotze, et al.; Cell Stress Chaperones
22, 879 (2017),
Abstract;
Full Text
The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System: A.C.D. Fuchs, et al.; Structure
25, 834 (2017),
Abstract;
Full Text
Bortezomib Amplifies Effect on Intracellular Proteasomes by Changing Proteasome Structure: D.S. Pitcher, et al.; EBioMedicine
2, 642 (2015),
Application(s): Fluorescence,
Abstract;
BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta: implications for a proteasome-to-autophagy switch: M. Minoia, et al.; Autophagy
10, 1603 (2014),
Abstract;
Full Text
The proteasomes of two marine decapod crustaceans, European lobster (Homarus gammarus) and Edible crab (Cancer pagurus), are differently impaired by heavy metals: S. Gotze, et al.; Comp. Biochem. Physiol. C Toxicol. Pharmacol.
162, 62 (2014),
Abstract;
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites: A. F. Kisselev, et al.; J Biol. Chem.
278, 35869 (2003),
Abstract;
Full Text
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