Highly specific inhibitor of the caspase-like peptidic activity of the 20S proteasome.
Product Details
| Sequence: | Ac-Ala-Pro-Nle-Asp-OH |
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| Formula: | C20H32N4O8 |
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| MW: | 456.5 |
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| Purity: | ≥95% (Reverse-Phase HPLC) |
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| Appearance: | Glassy lyophilized solid. |
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| Solubility: | Soluble in water:acetonitrile containing 0.1% TFA (3:1) at a concentration of 1mg/mL. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Once dissolved use solutions immediately and do not store. |
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| Handling: | Do not add buffers containing free amino groups as these will react with the aldehyde moiety thus inactivating the compound. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.: Kisselev, A.F., Garcia-Calvo, M., Overkleeft, H.S., Peterson, E., Pennington, M.W., Ploegh, H.L., Thornberry, N.A. and Goldberg, A.L. ; J Biol. Chem. 278, 35869-35877 (2003),
