Induces autophagy in HeLa cells followed by apoptotic cell death (IC50=10μM). This cellular response has been found to be mediated via inhibition of mTORC1 and induction of ER stress (IC50 for BT474 cells=2.5µM and MDAMB231 cells=6µM). The pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
Product Details
| Formula: | C39H64O13 |
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| MW: | 740.9 |
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| CAS: | 41059-79-4 |
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| Purity: | ≥96% (HPLC) |
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| Appearance: | White to off white solid. |
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| Solubility: | Soluble in DMSO (20 mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. Solutions can be stored at -20°C for up to 3 months. |
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| Handling: | Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress: F.W. King, et al.; PLoS ONE
4, e7283 (2009),
Abstract;
Full Text
Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice: B. Lee, et al.; Pharmacol. Biochem. Behav.
93, 121 (2009),
Abstract;
Timosaponin A-III induces autophagy preceding mitochondria-mediated apoptosis in HeLa cancer cells: L.K. Sy, et al.; Cancer Res.
68, 10229 (2008),
Abstract;
Full Text
