Gambogic Acid is a natural product isolated from Garcinia Hurburyi. It induces apoptosis in several tumor cell lines including T47D breast cancer cells and MGC-803 human gastric carcinoma cells but not in normal cells. Apoptosis induction proceeds via upregulation of bax and inhibition of bcl-2 expression.The target of gambogic acid has been identified as the transferrin receptor.
Product Details
| Formula: | C38H44O8 |
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| MW: | 628.8 |
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| CAS: | 2752-65-0 |
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| Purity: | ≥95% (TLC) |
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| Appearance: | Yellow-orange solid |
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| Solubility: | Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml) |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid: S. Kasibhatla, et al. ; Proc. Natl. Acad. Sci.
102, 12095 (2005),
Abstract;
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Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay: H.-Z. Zhang, et al.; Bioorg. Med. Chem.
12, 309 (2004),
Abstract;
Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells: L. Zhao, et al. ; Biol. Pharm. Bull.
27, 998 (2004),
Abstract;
