Replaces Prod. #: ALX-630-107
Anti-tumor agent. Induces apoptosis via DNA damage. Radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism. Inhibits intracellular DNA replication. DNA alkylating agent.
Product Details
Alternative Name: | Blenoxane |
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Formula: | C55H85N17O25S4 |
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MW: | 1512.6 |
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CAS: | 9041-93-4 |
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MI: | 14: 1318 |
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RTECS: | EC5991990 |
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Purity: | ≥98% (HPLC) |
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Appearance: | White crystalline solid. |
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Solubility: | Soluble in water (20mg/ml) or methanol. |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A Proximity Ligation Method to Detect Proteins Bound to Single-Stranded DNA after DNA End Resection at DNA Double-Strand Breaks: F.C. Fowler & J.K. Tyler; Methods Protoc.
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Abstract;
MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs: O. Keiji et al.; Oncotarget
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Full Text
ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks.: K.Y Lee et al.; Mol. Cell
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Full Text
Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer: S. Duffy, et al.; PNAS
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Application(s): Sensitivity to Genotoxic Agents, Yeast strains carrying each dCIN candidate
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Targeting Her-2+ breast cancer cells with bleomycin immunoliposomes linked to LLO: M. Kullberg, et al.; Mol. Pharm.
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Bleomycin-induced alterations in DNA replication: relationship to DNA damage: J. Dziegielewski, et al.; Biochemistry
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Bleomycin: new perspectives on the mechanism of action: S.M. Hecht; J. Nat. Prod.
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Synergistic effects of laserthermia and bleomycinsulfate on micronuclei formation in cytokinesis-blocked HeLa cells: A.S. Monfared & H. Mozdarani; Irn. J. Med. Sci. 24, 87 (1999),
Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models: M. Schirner, et al.; Clin. Cancer Res.
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Changes in c-Jun but not Bcl-2 family proteins in p53-dependent apoptosis of mouse cerebellar granule neurons induced by DNA damaging agent bleomycin: T. Araki, et al.; Brain Res.
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Induction of apoptosis by bleomycin in resting and cycling human lymphocytes: P. Vernole, et al.; Mutagenesis
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p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs: M. Muller, et al.; J. Exp. Med.
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Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens: J.G. Christensen, et al.; Cell Growth Differ.
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Sequence-specific changes in the metal site of ferric bleomycin induced by the binding of DNA: J.W. Sam, et al.; J. Biol. Chem.
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Cleavage of tRNA by Fe(II)-bleomycin: A. Huttenhofer, et al.; J. Biol. Chem.
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Chromatin structure during bleomycin-induced DNA damage and repair: B.P. Cuiffo, et al.; J. Free Radic. Biol. Med.
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Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin: J. Kross, et al.; Biochemistry
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