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Sulindac sulfone

Sulindac metabolite
BML-AP201-0005 5 mg 88.00 USD
BML-AP201-0025 25 mg 269.00 USD
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Replaces Prod. #: ALX-430-107

Induces apoptosis but does not inhibit cyclooxygenase. Inhibits growth and induces apoptosis in human cancer cell lines. Metabolite of Sulindac (Prod. No. ALX-430-105).

Product Details

Alternative Name:Z-5-Fluoro-2-methyl-1-[p-(methyl-sulfonyl)benzylidene]indene-3-acetic acid
Purity:≥94% (HPLC)
Appearance:Yellow solid.
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (3mg/ml, warm).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Sulindac inhibits activation of the NF-kappaB pathway: Y. Yamamoto, et al.; J. Biol. Chem. 274, 27307 (1999), Abstract;
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis: G.A. Piazza, et al.; Cancer Res. 55, 3110 (1995), Abstract;