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Caspase-8 assay kit for drug discovery

 
BML-AK715-0001 96 wells 636.00 USD
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NOW INCLUDES BOTH COLORIMETRIC AND FLUOROGENIC SUBSTRATES! This kit is a complete assay system to measure protease activity of caspase-8. Cleavage of a tetrapeptide substrate is monitored colorimetrically at 405 nm or fluorimetrically (Ex. 360 nm/Em. 460 nm). Assays are performed in a convenient 96-microwell plate format. These kits are useful for screening inhibitors of caspase-8. This kit is not intended for use in cellular extract assays.

Product Details

Alternative Name:FLICE, Mch5, MACH
 
Applications:Colorimetric detection, Fluorescence microscopy, HTS
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Contents:Caspase-8 enzyme (human) (recombinant), Ac-IETD-pNA colorimetric substrate, Ac-IETD-AMC fluorimetric substrate, calibration standards, aldehyde inhibitor, assay buffer, 1/2-volume 96-microwell plate, and instruction booklet.
 
Technical Info/Product Notes:Biocompare Article: Keep an Eye on Apoptosis with Caspase Assays
 
UniProt ID:Q14790
 
Regulatory Status:RUO - Research Use Only
 
Compatibility:This product is compatible with the Absorbance 96 Plate Reader.

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Product Literature References

A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils: B. Geering, et al.; Blood 117, 5953 (2011), Abstract; Full Text

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