A QUANTIZYME® Assay System. The MMP-14 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay sytem designed to screen for inhibitors of matrix metalloproteinase-14 (MMP-14, membrane-type matrix metalloproteinase 1, MT1-MMP) using a quenched fluorogenic peptide: OMNIMMP® fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. Also included are active enzyme, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet.
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Product Details
| Alternative Name: | Membrane type matrix metalloproteinase 1, MT-1 MMP |
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| Applications: | Fluorescent detection, HTS
Activity assay
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Contents: | MMP-14 enzyme (human) (recombinant), substrate, calibration standard, Assay Buffer, 96-well white microplate. |
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| UniProt ID: | P45452 |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The effects of Candida proteinases on human proMMP-9, TIMP-1 and TIMP-2: P. Parnaren, et al.; Mycoses
54, 325 (2011),
Abstract;
