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MMP Inhibitor profiling kit, fluorometric

BML-AK016-0001 96 wells 1,254.00 USD
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A QUANTIZYME® Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a sensitive fluorogenic substrate . Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet.

Product Details

Applications:Fluorescent detection, HTS
Activity assay
Shipping:Dry Ice
Long Term Storage:-80°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Amphiphilic peptide-based MMP3 inhibitors for intra-articular treatment of knee OA: C. Guarise, et al.; Bioorg. Med. Chem. 38, 116132 (2021), Abstract;
An integrated structure- and pharmacophore-based MMP-12 virtual screening: M. Ramezani, et al.; Mol. Divers. 22, 383 (2018), Abstract;
Rosmarinic acid counteracts activation of hepatic stellate cells via inhibiting the ROS-dependent MMP-2 activity: Involvement of Nrf2 antioxidant system: C. Lu, et al.; Toxicol. Appl. Pharmacol. 318, 69 (2017), Abstract;
Virtual Screening on MMP-13 Led to Discovering New Inhibitors Including a Non-Zinc Binding and a Micro Molar One: A Successful Example of Receptor Selection According to Cross-Docking Results for a Flexible Enzyme: M. Ramezani, et al.; Comb. Chem. High Throughput Screen 20, 719 (2017), Abstract;
Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8: D. Demeestere, et al.; Mol. Ther. 2016, 890 (2016), Abstract; Full Text
Hyaluronic acid alkyl derivative: A novel inhibitor of metalloproteases and hyaluronidases: M. Pavan, et al.; Int. J. Biol. Macromol. 84, 221 (2016), Abstract;
Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases: M. Brkic, et al.; J. Neurosci. 35, 12766 (2015), Abstract;
Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory Activity In Vitro and In Vivo: J. Aerts, et al.; Mediators Inflamm. 2015, 510679 (2015), Abstract; Full Text
A novel matrix metalloproteinase-2 inhibitor triazolylmethyl aziridine reduces melanoma cell invasion, angiogenesis and targets ERK1/2 phosphorylation: N. Romanchikova, et al.; J. Enzyme Inhib. Med. Chem. 29, 765 (2014), Abstract;
Inhibitory effects of dried longan (Euphoria longana Lam.) seed extract on invasion and matrix metalloproteinases of colon cancer cells: A. Panyathep, et al.; J. Agric. Food Chem. 61, 3631 (2013), Abstract;
Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer: T. Fujisawa, et al.; PLoS One 7, e34437 (2012), Application(s): IC50 of cysteamine and batimastat, Abstract; Full Text
Development and validation of novel enzyme activity methods to assess inhibition of matrix metalloproteinases (MMPs) in human serum by antibodies against enzyme therapeutics: T.J. Edkins, et al.; J. Pharm. Biomed. Anal. 70, 408 (2012), Abstract;
Functional characterization of Kunitz-type protease inhibitor Pr-mulgins identified from New Guinean Pseudechis australis: H. Inagki, et al.; Toxicon 59, 74 (2012), Abstract;
Potent "clicked" MMP2 inhibitors: synthesis, molecular modeling and biological exploration: J.M. Zapico, et al.; Org. Biomol. Chem. 9, 4587 (2011), Abstract;

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