Lincosamide antibiotic. 23S Inhibits bacterial protein synthesis. Active against Gram-positive bacteria. Lincomycin binds to the 50S subunit of bacterial ribosomes and suppresses protein synthesis.
Product Details
| Alternative Name: | U-10149A |
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| Formula: | C18H34N2O6S.HCl.H2O |
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| MW: | 443.0 |
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| Source: | Isolated from Streptomyces lincolnensis |
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| CAS: | 7179-49-9 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in water (50mg/ml) |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at 0-4°C for up to 2 years. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Lincomycin protects mice from septic shock in beta-glucan-indomethacin model: S. Nameda et al.; Biol. Pharm. Bull.
30, 2312 (2007),
Abstract;
Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics: W.S. Champney & C.L. Tober; Curr. Microbiol.
41, 126 (2000),
Abstract;
Peptidyl transferase antibiotics perturb the relative positioning of the 3'-terminal adenosine of P/P'-site-bound tRNA and 23S rRNA in the ribosome: S.V. Kirillow et al.; Rna
5, 1003 (1999),
Abstract;
Slow-onset inhibition of ribosomal peptidyltransferase by lincomycin: S. Kallia-Raftopoulos et al.; Arch. Biochem. Biophys.
298, 332 (1992),
Abstract;
Microbial kinetics of drug action against gram-positive and gram-negative organisms. III: Effect of lincomycin and clindamycin combinations on Staphylococcus aureus and Escherichia coli: S.M. Heman-Ackah et al.; J. Pharm. Sci.
64, 1621 (1975),
Abstract;
Animal Toxicity Studies of a New Antibiotic, Lincomycin: J. Grey et al.; Toxicol. Appl. Pharmacol.
6, 476 (1964),
Abstract;
