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Kasugamycin . hydrochloride

Aminoglycoside antibiotic and pesticide
BML-A239-0001 1 g 89.00 USD
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Replaces Prod. #: ALX-380-076

A unique aminoglycoside antibiotic which binds to the 30S subunit of bacterial ribosomes and suppresses protein synthesis. Unlike most aminoglycoside antibiotics which exhibit broad activity against both Gram-positive and Gram-negative bacteria, kasugamycin exhibits limited activity against phytopathogenic microbes. Used as a pesticide. Binds to the 30S subunit of bacterial ribosome and suppresses protein synthesis. Inhibits translation initiation of canonical but not of leaderless messenger RNAs.

Product Details

Formula:C14H25N3O9 . HCl
Source:Isolated from Streptomyces kasugaensis
Purity:≥90% (HPLC)
Appearance:White to tan solid.
Solubility:Soluble in water
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
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Product Literature References

The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation: F. Schluenzen et al.; Nat. Struct. Mol. Biol. 13, 871 (2006), Abstract;
Differential inhibition of 30S and 70S translation initiation complexes on leaderless mRNA by kasugamycin: I. Moll & U.Blasi; Biochem. Biophys. Res. Commun. 297, 1021 (2002), Abstract;
Comparative studies on in vitro activities of kasugamycin and clinically-used aminoglycoside antibiotics: T. Tamamura & K. Sato; Jpn. J. Antibiot. 52, 57 (1999), Abstract;
Protein folding in Escherichia coli: role of 23S ribosomal RNA: S. Chattopadhyay et al.; Biochim. Biophys. Acta. 1429, 293 (1999), Abstract;
A New Antibiotic, Kasugamycin: H. Umezawa et al.; J. Antibiot. (Tokyo) 18, 101 (1965), Abstract;
Pharmacology of Kasugamycin and the Effect on Pseudomonas Infection: T. Takeuchi et al.; J. Antibiot. (Tokyo) 18, 107 (1965), Abstract;

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