Replaces Prod. #: ALX-380-076
A unique aminoglycoside antibiotic which binds to the 30S subunit of bacterial ribosomes and suppresses protein synthesis. Unlike most aminoglycoside antibiotics which exhibit broad activity against both Gram-positive and Gram-negative bacteria, kasugamycin exhibits limited activity against phytopathogenic microbes. Used as a pesticide. Binds to the 30S subunit of bacterial ribosome and suppresses protein synthesis. Inhibits translation initiation of canonical but not of leaderless messenger RNAs.
Product Details
| Formula: | C14H25N3O9 . HCl |
| |
| MW: | 415.8 |
| |
| Source: | Isolated from Streptomyces kasugaensis |
| |
| CAS: | 19408-46-9 |
| |
| Purity: | ≥90% (HPLC) |
| |
| Appearance: | White to tan solid. |
| |
| Solubility: | Soluble in water |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation: F. Schluenzen et al.; Nat. Struct. Mol. Biol.
13, 871 (2006),
Abstract;
Differential inhibition of 30S and 70S translation initiation complexes on leaderless mRNA by kasugamycin: I. Moll & U.Blasi; Biochem. Biophys. Res. Commun.
297, 1021 (2002),
Abstract;
Comparative studies on in vitro activities of kasugamycin and clinically-used aminoglycoside antibiotics: T. Tamamura & K. Sato; Jpn. J. Antibiot.
52, 57 (1999),
Abstract;
Protein folding in Escherichia coli: role of 23S ribosomal RNA: S. Chattopadhyay et al.; Biochim. Biophys. Acta.
1429, 293 (1999),
Abstract;
A New Antibiotic, Kasugamycin: H. Umezawa et al.; J. Antibiot. (Tokyo)
18, 101 (1965),
Abstract;
Pharmacology of Kasugamycin and the Effect on Pseudomonas Infection: T. Takeuchi et al.; J. Antibiot. (Tokyo)
18, 107 (1965),
Abstract;
