Replaces Prod. #: ALX-380-046
Mixture of alamethicin homologs. Membrane permeabilizing antibiotic. Applications include increasing [32P] incorporation into phosphatidylinositol 4-phosphate and permeabilization of sarcoplasmic reticulum vesicles. Causes fusion of lipid vesicles.
Product Details
Alternative Name: | U-22324 |
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Sequence: | Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Gln-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Gln-L-phenylalaninol |
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Formula: | C92H150N22O25 |
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MW: | 1964.3 |
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CAS: | 27061-78-5 |
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Purity: | ≥98% (TLC) |
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Appearance: | White to off-white solid. |
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Solubility: | Soluble in DMSO, 100% ethanol or methanol. |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins: C. Alcon, et al.; Cells
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Abstract;
Channel-forming activity of alamethicin: effects of covalent tethering: G.A. Woolley; Chem. Biodivers.
4, 1323 (2007), Review,
Abstract;
Ligand-induced extramembrane conformation switch controlling alamethicin assembly and the channel current: S. Futaki & K. Asami; Chem. Biodivers.
4, 1313 (2007), Review,
Abstract;
Model ion channels: gramicidin and alamethicin: G. A. Woolley & B. A. Wallace; J. Membr. Biol.
129, 109 (1992), Review,
Abstract;
Regulation of polyphosphoinositide synthesis in cardiac membranes: E. Quist, et al.; Arch. Biochem. Biophys.
271, 21 (1989),
Abstract;
The production of alamethicins by Trichoderma spp: D. Brewer, et al.; Can. J. Microbiol.
33, 619 (1987),
Abstract;
Adenylate cyclase in sarcoplasmic reticulum of skeletal muscle: distribution, orientation, and regulation: M. Nakagawa & J.H. Willner; J. Cyclic Nucleotide Protein Phosphor. Res.
11, 237 (1986),
Abstract;
The use of ionophores and channel formers in the study of the function of biological membranes: A. Gomez-Puyou & C. Gomez-Lojero; Curr. Top. Bioener. 6, 221 (1977),
Alamethicin-mediated fusion of lecithin vesicles: A.L.Y. Lau and S.I. Chan; PNAS
72, 2170 (1975),
Abstract;
The primary structure of alamethicin: J.W. Payne, et al.; Biochem. J.
117, 757 (1970),
Abstract;