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Alamethicin

Antibiotic that increases membrane permeability



BML-A150-0005	5 mg	219.00 USD

BML-A150-0025	25 mg	648.00 USD
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Replaces Prod. #: ALX-380-046

Mixture of alamethicin homologs. Membrane permeabilizing antibiotic. Applications include increasing [³²P] incorporation into phosphatidylinositol 4-phosphate and permeabilization of sarcoplasmic reticulum vesicles. Causes fusion of lipid vesicles.

Product Details

Alternative Name:	U-22324

Sequence:	Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Gln-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Gln-L-phenylalaninol

Formula:	C₉₂H₁₅₀N₂₂O₂₅

MW:	1964.3

CAS:	27061-78-5

Purity:	≥98% (TLC)

Appearance:	White to off-white solid.

Solubility:	Soluble in DMSO, 100% ethanol or methanol.

Shipping:	Ambient

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment: C. Alcon, et al.; Cell Death Discov. 8, 172 (2022), Abstract;

ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins: C. Alcon, et al.; Cells 10, 1659 (2021), Abstract;

Channel-forming activity of alamethicin: effects of covalent tethering: G.A. Woolley; Chem. Biodivers. 4, 1323 (2007), Review, Abstract;

Ligand-induced extramembrane conformation switch controlling alamethicin assembly and the channel current: S. Futaki & K. Asami; Chem. Biodivers. 4, 1313 (2007), Review, Abstract;

Model ion channels: gramicidin and alamethicin: G. A. Woolley & B. A. Wallace; J. Membr. Biol. 129, 109 (1992), Review, Abstract;

Regulation of polyphosphoinositide synthesis in cardiac membranes: E. Quist, et al.; Arch. Biochem. Biophys. 271, 21 (1989), Abstract;

The production of alamethicins by Trichoderma spp: D. Brewer, et al.; Can. J. Microbiol. 33, 619 (1987), Abstract;

Adenylate cyclase in sarcoplasmic reticulum of skeletal muscle: distribution, orientation, and regulation: M. Nakagawa & J.H. Willner; J. Cyclic Nucleotide Protein Phosphor. Res. 11, 237 (1986), Abstract;

The use of ionophores and channel formers in the study of the function of biological membranes: A. Gomez-Puyou & C. Gomez-Lojero; Curr. Top. Bioener. 6, 221 (1977),

Alamethicin-mediated fusion of lecithin vesicles: A.L.Y. Lau and S.I. Chan; PNAS 72, 2170 (1975), Abstract;

The primary structure of alamethicin: J.W. Payne, et al.; Biochem. J. 117, 757 (1970), Abstract;