The SCREEN-WELL® Hepatotoxicity Library is a focused collection of 238 compounds with defined and diverse hepatotoxicity, including steatosis, mitochondrial toxicity, Mallory body formation, cholestatic effects, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.
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Product Literature References
A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®: K.M. Bircsak, et al.; Toxicology
450, 152667 (2021),
Abstract;
High-fidelity drug-induced liver injury screen using human pluripotent stem cell–derived organoids: T. Shinozawa, et al.; Gastroenterology.
160, 831 (2021),
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Live‐cell screening platform using human‐induced pluripotent stem cells expressing fluorescence‐tagged cytochrome P450 1A1: J.W. Kim, et al.; FASEB J.
34, 9141 (2020),
Abstract;
Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury: M.T. Donato, et al.; Differentiation
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The convergence of stem cell technologies and phenotypic drug discovery: A. Friese, et al.; Cell Chem. Biol.
26, 1050 (2019),
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High-Content Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell-Derived Cells: O. Sirenko, et al.; Assay Drug Dev. Technol.
12, 43 (2014),
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