The SCREEN-WELL® REDOX library contains 83 compounds with defined prooxidant or antioxidant activity. Compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates at 100 or 500µl per well.A variety of structurally and mechanistically different compound classes are included such as hydroperoxides, polyphenolics, metal chelators, thiols, thiol traps, radical scavengers, lazaroids and glutathione modulators as well as small molecule enzyme mimetics for SOD and glutathione peroxidase. The library is a useful tool for studying the roles of pro- and antioxidant molecules in cells as well as for use in in vitro applications.
Product Details
| Applications: | HTS
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| Use/Stability: | Stable for at least one year from the date of receipt when stored at -80°C. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Technical Info/Product Notes: |  |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for retinitis pigmentosa: L. Ganzen, et al.; Sci. Rep.
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Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma: R.M. Robinson, et al.; Leukemia
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Small-Molecule Screens Reveal Novel Haustorium Inhibitors in the Root Parasitic Plant Triphysaria versicolor: Y. Wang, et al.; Phytopathology
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Identification and characterization of compounds that affect stomatal movements: S. Toh, et al.; Plant Cell Physiol.
59, 1568 (2018),
Abstract;
Larval Zebrafish Lateral Line as a Model for Acoustic Trauma: P. Uribe, et al.; eNeuro
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Abstract;
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Screening antioxidants for the protection of cochlear sensory cells: D.G. Hur, et al.; Neural Regen. Res.
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An antioxidant screen identifies candidates for protection of cochlear hair cells from gentamicin toxicity: V. Noack, et al.; Front. Cell. Neurosci.
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Abstract;
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Pharmacological stimulation of nuclear factor (erythroid-derived 2) -like 2 translation activates antioxidant responses: O. Perez-Leal, et al.; J. Biol. Chem.
292, 14108 (2017),
Abstract;
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Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury: S. Martens, et al.; Cell Death Dis.
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Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2: D.C. Angeles, et al.; Ann. Clin. Transl. Neurol.
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Tousled kinase activator, gallic acid, promotes homologous recombinational repair and suppresses radiation cytotoxicity in salivary gland cells: P.S.T. Shanmugam, et al.; Free Radic. Biol. Med.
93, 217 (2016),
Abstract;
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Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1: M. Kawarski, et al.; Chem. Biol. Drug Des.
86, 1049 (2015),
Application(s): Screened against caspase-1,
Abstract;
Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency: M.J. Son, et al.; Cell Death Differ.
22, 1957 (2015),
Application(s): Functional Studies,
Abstract;
Effects of Redox state on the efficient uptake of cell permeable peptide in mammalian cells: S. Squires, et al.; Open Biochem. J.
7, 54 (2013),
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