The SCREEN-WELL® REDOX library contains 83 compounds with defined prooxidant or antioxidant activity. Compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates at 100 or 500µl per well.A variety of structurally and mechanistically different compound classes are included such as hydroperoxides, polyphenolics, metal chelators, thiols, thiol traps, radical scavengers, lazaroids and glutathione modulators as well as small molecule enzyme mimetics for SOD and glutathione peroxidase. The library is a useful tool for studying the roles of pro- and antioxidant molecules in cells as well as for use in in vitro applications.
Product Specification
| Applications: | HTS
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| Use/Stability: | Stable for at least one year from the date of receipt when stored at -80°C. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Technical Info/Product Notes: |  |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Small-Molecule Screens Reveal Novel Haustorium Inhibitors in the Root Parasitic Plant Triphysaria versicolor: Y. Wang, et al.; Phytopathology (2019),
Abstract;
Larval Zebrafish Lateral Line as a Model for Acoustic Trauma: P. Uribe, et al.; eNeuro
5, ENEURO.0206-18.2018 (2018),
Abstract;
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Screening antioxidants for the protection of cochlear sensory cells: D.G. Hur, et al.; Neural Regen. Res.
13, 62 (2018),
Abstract;
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Pharmacological stimulation of nuclear factor (erythroid-derived 2) -like 2 translation activates antioxidant responses: O. Perez-Leal, et al.; J. Biol. Chem.
292, 14108 (2017),
Abstract;
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Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury: S. Martens, et al.; Cell Death Dis.
8, e2904 (2017),
Abstract;
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Antioxidants inhibit neuronal toxicity in Parkinson's disease-linked LRRK2: D.C. Angeles, et al.; Ann. Clin. Transl. Neurol.
3, 288 (2016),
Abstract;
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Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1: M. Kawarski, et al.; Chem. Biol. Drug Des.
86, 1049 (2015),
Application(s): Screened against caspase-1,
Abstract;
Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency: M.J. Son, et al.; Cell Death Differ.
22, 1957 (2015),
Application(s): Functional Studies,
Abstract;
Effects of Redox state on the efficient uptake of cell permeable peptide in mammalian cells: S. Squires, et al.; Open Biochem. J.
7, 54 (2013),
Abstract;
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