The SCREEN-WELL® Orphan ligand library contains 84 compounds with defined, putative, potential or speculative biological activity but whose protein binding partners have not been identified. Ligands are supplied dissolved in biocompatible solvents at 10mM and aliquoted into a deep-well plate at 500µl per well. The library is a rich source of ligands for receptor de-orphaning. Includes the following classes of ligands: Trace Amines, Neurotransmitter Metabolites, Endogenous β-carbolines, Urinary Metabolites, Nicotine Congeners, D-Amino Acids. Receptors for endogenous trace amines have been deorphanized. Endogenous β-carbolines have been shown to display varied biological effects such as hallucinations, hypotension and others. Nicotine congeners such as nornicotine are biologically active and may act at novel nicotinic receptor subtypes.
Product Details
| Applications: | HTS
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| Quantity: | 84 compounds, 500μl per compound |
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| Use/Stability: | Stable for at least one year from the date of receipt when stored at -80°C. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Technical Info/Product Notes: |  |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Tryptophan and kynurenine enhances the stemness and osteogenic differentiation of bone marrow-derived mesenchymal stromal cells in vitro and in vivo: H.T. Pham, et al.; Materials (Basel)
14, 208 (2021),
Abstract;
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High-throughput screening identifies two novel small molecule enhancers of recombinant protein expression: J. Chang, et al.; Molecules
25, 353 (2020),
Abstract;
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New functions of classical compounds against orofacial inflammatory lesions: N.H. Moritani, et al.; Medicines (Basel)
5, 118 (2018),
Abstract;
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Fluocinolone acetonide is a potent synergistic factor of TGF-β3-associated chondrogenesis of bone marrow-derived mesenchymal stem cells for articular surface regeneration: E.S. Hara, et al.; J. Bone Miner. Res.
30, 1585 (2015),
Abstract;
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Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay: H. Yin, et al.; J. Biol. Chem.
284, 12328 (2009),
Abstract;
Full Text
A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators: P. Stoilov, et al.; PNAS
105, 11218 (2008),
Abstract;
A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation: J. P. Saxe; Chem. Biol.
14, 1019 (2007),
Abstract;
Identification of orphan G protein-coupled receptor ligands using FLIPR assays: N.M. Robas, et al.; Methods Mol. Biol.
306, 17 (2005),
Abstract;
General Literature References
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay: H. Yin, et al.; J. Biol. Chem.
284, 12328 (2009),
Abstract;
