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SCREEN-WELL® Bioactive lipid library

BML-2800-0100 1 Library 100 µl/well 6,551.00 USD
BML-2800-0500 1 Library 500 µl/well 16,341.00 USD
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The SCREEN-WELL® Bioactive Lipid Library contains 190 bioactive lipids in a 96 well format. Ideal for screening or identifiying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays and for routine pharmacological applications.

Product Details

Contents:190 compounds including: Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids.
Quantity:100 or 500µl per well.
Concentration:DMSO solutions (1.0 or 0.1mM, depending on compound).
Use/Stability:Stable for at least one year from the date of receipt when stored at -80°C.
Shipping:Dry Ice
Long Term Storage:-80°C
Technical Info/Product Notes:
Regulatory Status:RUO - Research Use Only

Product Literature References

Molecular basis for the interaction of cellular retinol-binding protein 2 (CRBP2) with non-retinoid ligands: J. Silvaroli, et al.; J. Lipid Res. 62, 100054 (2021), Abstract;
Mechanism of activation for the sirtuin 6 protein deacylase: M.A. Klein, et al.; J. Biol. Chem. 295, 1385 (2020), Abstract; Full Text
Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1: J.A. Silvaroli, et al.; ACS Chem. Biol. 14, 434 (2019), Abstract; Full Text
Brown Adipogenic Reprogramming Induced by a Small Molecule: B. Nie, et al.; Cell Rep. 18, 624 (2017), Abstract;
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest. 127, 2739 (2017), Abstract; Full Text
AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells: T. Yoshinaga, et al.; PLoS One 11, e0167848 (2016), Abstract; Full Text
Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells: J.H. Rhim, et al.; Sci. Rep. 6, 26547 (2016), Abstract; Full Text
Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans: P.R. Rodrigues, et al.; G3 (Bethesda) 6, 1695 (2016), Abstract; Full Text
Targeting surface voids to counter membrane disorders in lipointoxication-related diseases: R. Ferru-Clément, et al.; J. Cell. Sci. 129, 2368 (2016), Abstract;
The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication: M. Carocci, et al.; Antimicrob. Agents Chemother. 59, 85 (2015), Abstract; Full Text
A Novel Small Molecule Methyltransferase Is Important for Virulence in Candida albicans: E. Lissina, et al.; ACS Chem. Biol. 8, 2785 (2013), Abstract; Full Text
Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity: S. Yin, et al.; J. Clin. Invest. 123, 3941 (2013), Application(s): Library Assay, Abstract; Full Text
Human pluripotent stem cells: the development of high-content screening strategies: S.P. Sherman, et al.; Methods Mol. Biol. 767, 283 (2011), Application(s): HCS Assay, Abstract;
Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist: A.J. Brown, et al.; J. Pharmacol. Exp. Ther. 337, 226 (2011), Application(s): Library Assay, Abstract; Full Text
Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress: I. Martins, et al.; Oncogene 30, 1147 (2011), Abstract;
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay: H. Yin, et al.; J. Biol. Chem. 284, 12328 (2009), Abstract;
Lipid G protein-coupled receptor ligand identification using β-arrestin PathHunter™ assay: H. Yin, et al.; J. Biol. Chem. 284, 12328 (2009), Abstract; Full Text
A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators: P. Stoilov, et al.; PNAS 105, 11218 (2008), Abstract;
Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18: M. Kohno, et al.; BBRC 347, 827 (2006), Abstract;
A glance at G-protein-coupled receptors for lipid mediators: a growing receptor family with remarkably diverse ligands: E. Kostenis, et al.; Pharmacol. Ther. 102, 243 (2004), Abstract;
Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family: K. Noguchi, et al.; J. Biol. Chem. 278, 25600 (2003), Abstract;

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