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TL1A soluble (human), ELISA kit

APO-54N-027-KI01 96 wells Inquire for pricing
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The TL1A soluble (human), ELISA kit is a complete assay for the quantitative determination of soluble human TL1A concentration. This kit is to be used with biological fluids (serum and cell culture supernatant) from human origin.

Product Details

Alternative Name:TNFSF 15, VEGI
Sensitivity:15pg/ml (range 39 to 2500pg/ml).
Assay Time:<3 hours
Applications:ELISA, Colorimetric detection
Application Notes:For the quantitative determination of soluble human TL1A from biological fluids (serum and cell culture supernatant).
Wavelength:450 nm
Species reactivity:Human
Handling:Keep the standard and antibodies at -20°C until use. Avoid freeze/thaw cycles.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:TL1A (TNFSF15), a ligand belonging to the tumor necrosis factor (TNF) family, is expressed predominantly by endothelial cells and monocytes. TL1a is upregulated by the proinflammatory cytokines TNF and IL-1 and also by immune complexes (IC). TL1 functions in T cell costimulation and Th1 polarization. On activated T cells, TL1A functions specifically via its surface-bound receptor DR3, (a member of the death-domain containing TNF receptor family) to promote cell survival and secretion of proinflammatory cytokines. The secreted decoy receptor 3 (DcR3), a soluble protein of the tumor necrosis factor receptor (TNFR) superfamily blocks the action of TL1A. TL1A can be released to circulate as a homotrimeric soluble form. Activation of DR3 by TL1A induced the formation of a signaling complex containing TRADD, TRAF2, and RIP and activated the NF-κB and the ERK, JNK, and p38 mitogen-activated protein kinase pathways. The TL1A/DR3 pathway plays an important role in Th1-mediated intestinal diseases, such as Crohn’s disease.
UniProt ID:O95150
Regulatory Status:RUO - Research Use Only
Compatibility:This product is compatible with the Absorbance 96 Plate Reader.

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General Literature References

Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis: M.A. Cassatella, et al.; J. Immunol. 178, 7325 (2007), Abstract;
Identification of naturally secreted soluble form of TL1A, a TNF-like cytokine: S. Kim & L. Zhang; J. Immunol. Methods 298, 1 (2005), Abstract;
Enhanced adhesion of monocytes via reverse signaling triggered by decoy receptor 3: M.J. Hsu, et al.; Exp. Cell Res. 292, 241 (2004), Abstract;
Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease: G. Bamias, et al.; J. Immunol. 171, 4868 (2003), Abstract;
TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells: L. Wen, et al.; J. Biol. Chem. 278, 39251 (2003), Abstract;
TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator: T.S. Migone, et al.; Immunity 16, 479 (2002), Abstract;

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