Product Details
| Alternative Name: | TPO |
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| Clone: | TPO 47 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Human TPO (thyroid peroxidase). |
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| UniProt ID: | P07202 |
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| Species reactivity: | Human
|
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| Specificity: | Recognizes a linear epitope (aa 713-721) on human TPO protein. |
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| Applications: | IHC (PS), WB
|
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| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections)
Western Blot (dilution 1:2-1:10). |
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| Application Notes: | Assists immunocytological diagnosis of malignancy on fine needle aspirates (FNA) of thyroid nodules. Strongly stains human TPO in normal thyroid tissues but does not recognize tumoral human TPO. |
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| Formulation: | Sterile supernatant. 0.6 - 0.9g/ml. Contains 0.1% sodium azide. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity: D.O. McDonald & S.H. Pearce; J. Mol. Med.
87, 971 (2009),
Abstract;
Full Text
BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer: C. Romei, et al.; Endocr. Relat. Cancer
2, 511 (2008),
Abstract;
Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma: M. Landriscina, et al.; J. Clin. Endocrinol. Metab.
90, 5663 (2005),
Abstract;
Full Text
Type I interferons modulate the expression of thyroid peroxidase, sodium/iodide symporter, and thyroglobulin genes in primary human thyrocyte cultures: N. Caraccio, et al.; J. Clin. Endocrinol. Metab.
90, 1156 (2005),
Abstract;
Full Text
Molecular model, calcium sensitivity, and disease specificity of a conformational thyroperoxidase B-cell epitope: V. Estienne, et al.; J. Biol. Chem.
274, 35313 (1999),
Abstract;
Full Text
A conformational B-cell epitope on the C-terminal end of the extracellular part of human thyroid peroxidase: V. Estienne, et al.; J. Biol. Chem.
273, 8056 (1998),
Abstract;
Full Text
Current Evaluation of Thyroid Nodules: H. Gharib; Trends Endocrinol. Metab.
5, 365 (1994),
Abstract;
Fine-needle aspiration of thyroid follicular neoplasm: diagnostic use of thyroid peroxidase immunocytochemistry with monoclonal antibody 47: C. De Micco, et al.; Surgery
116, 1031 (1994),
Abstract;
Malignancy markers in the cytodiagnosis of thyroid nodules. Thyroid peroxidase: C. De Micco, et al.; Ann. Pathol.
14, 378 (1994),
Abstract;
Thyroid peroxidase immunodetection as a tool to assist diagnosis of thyroid nodules on fine-needle aspiration biopsy: C. De Micco, et al.; Eur. J. Endocrinol.
131, 474 (1994),
Abstract;
Thyroperoxidase immunodetection for the diagnosis of malignancy on fine- needle aspiration of thyroid nodules: J.-F. Henry, et al.; World J. Surg.
18, 529 (1994),
Abstract;
Immunohistochemical study of thyroid peroxidase in normal, hyperplastic, and neoplastic human thyroid tissues: C. De Micco, et al.; Cancer
67, 3036 (1991),
Abstract;
Relationship between immunological structure and biochemical properties of human thyroid peroxidase: J. Ruf, et al.; Endocrinology
125, 1211 (1989),
Abstract;
