| Alternative Name: | HLA Class I |
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| Clone: | W6/32 |
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| Host: | Mouse |
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| Isotype: | IgG2a |
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| Immunogen: | Membrane of human tonsil cells. |
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| Species reactivity: | Human
Bovine, Cat, Monkey
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| Specificity: | The antibody W6/32 recognises an extracellular epitope of MHC Class I molecules (MHC Class Ia) that are expressed on the surface of all human nucleated cell types. This antibody W6/32 is also suitable as a positive control for HLA tissue typing and crossmatching. |
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| Applications: | Flow Cytometry
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| Purity Detail: | Protein G-affinity purified. The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
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| Formulation: | Liquid. In PBS, containing 15mM sodium azide. |
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| Handling: | Do not freeze. Protect from light. |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | +4°C |
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| Scientific Background: | HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules. |
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| Regulatory Status: | RUO - Research Use Only |
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