Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.
Product Details
| Alternative Name: | TNFRSF 5 |
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| Clone: | FGK45 |
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| Host: | Rat |
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| Isotype: | IgG2a |
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| Immunogen: | Recombinant mouse CD40 fusion protein. |
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| UniProt ID: | P27512 |
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| Source: | Purified from hybridoma tissue culture supernatant |
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| Species reactivity: | Mouse
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| Applications: | Flow Cytometry
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In sterile PBS. |
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| Handling: | Do not freeze. Protect from light. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Two-color analysis of the expression of CD40 on mouse spleen cells. Splenocytes were simultaneously stained with APC-conjugated anti-B220 MAb and biotinylated FGK45 MAb to CD40 (Prod. No.
ALX-805-046) followed by a streptavidin-R-PE conjugate. Specificity of FGK45 towards CD40 was confirmed on splenocytes from -/- CD40 mice and a biotin-conjugated isotype control."
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Product Literature References
Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus: C. Bartholdy, et al.; J. Immunol.
178, 1662 (2007),
Abstract;
IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling: P.W. Hellings, et al.; J. Immunol.
177, 5138 (2006),
Abstract;
In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN: J.A. Greene, et al.; J. Immunol.
176, 5995 (2006),
Abstract;
IRF-7 is the master regulator of type-I interferon-dependent immune responses: K. Honda, et al.; Nature
434, 772 (2005),
Abstract;
CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes: C.M. McGregor, et al.; PNAS
101, 9345 (2004),
Abstract;
Full Text
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system: A. Erlebacher, et al.; J. Clin. Invest.
114, 39 (2004),
Abstract;
Full Text
Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells: J.G. Turner, et al.; J. Immunol.
166, 89 (2001),
Abstract;
Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process: C. Mauri, et al.; Nat. Med.
6, 673 (2000),
Abstract;
Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity: A.G. Rolink, et al.; Eur. J. Immunol.
28, 3738 (1998),
Abstract;
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching: A. Rolink, et al.; Immunity
5, 319 (1996),
Abstract;
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