Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

CD40 (mouse) monoclonal antibody (FGK45) (biotin conjugate)

ALX-805-046B-C050 50 µg Biotin 256.00 USD
Do you need bulk/larger quantities?
Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

Product Details

Alternative Name:TNFRSF 5
Immunogen:Recombinant mouse CD40 fusion protein.
UniProt ID:P27512
Source:Purified from hybridoma tissue culture supernatant
Species reactivity:Mouse
Applications:ELISA, Flow Cytometry
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In sterile PBS.
Handling:Do not freeze. Protect from light.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:+4°C
Regulatory Status:RUO - Research Use Only
CD40 (mouse) monoclonal antibody (FGK45) (biotin conjugate) FACS
Figure: Two-color analysis of the expression of CD40 on mouse spleen cells. Splenocytes were simultaneously stained with APC-conjugated anti-B220 MAb and biotinylated FGK45 MAb to CD40 (Prod. No. ALX-805-046) followed by a streptavidin-R-PE conjugate. Specificity of FGK45 towards CD40 was confirmed on splenocytes from -/- CD40 mice and a biotin-conjugated isotype control."
Please mouse over
CD40 (mouse) monoclonal antibody (FGK45) (biotin conjugate) FACS

Product Literature References

Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus: C. Bartholdy, et al.; J. Immunol. 178, 1662 (2007), Abstract;
IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling: P.W. Hellings, et al.; J. Immunol. 177, 5138 (2006), Abstract;
In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN: J.A. Greene, et al.; J. Immunol. 176, 5995 (2006), Abstract;
IRF-7 is the master regulator of type-I interferon-dependent immune responses: K. Honda, et al.; Nature 434, 772 (2005), Abstract;
CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes: C.M. McGregor, et al.; PNAS 101, 9345 (2004), Abstract; Full Text
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system: A. Erlebacher, et al.; J. Clin. Invest. 114, 39 (2004), Abstract; Full Text
Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells: J.G. Turner, et al.; J. Immunol. 166, 89 (2001), Abstract;
Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process: C. Mauri, et al.; Nat. Med. 6, 673 (2000), Abstract;
Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity: A.G. Rolink, et al.; Eur. J. Immunol. 28, 3738 (1998), Abstract;
The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching: A. Rolink, et al.; Immunity 5, 319 (1996), Abstract;

Related Products

CD40 (mouse) monoclonal antibody (FGK45) 

Purified from hybridoma tissue culture supernatant., ELISA, Flow Cytometry, WB, FUNC | Print as PDF
ALX-805-046-C100 100 µg 243.00 USD
ALX-805-046-C500 500 µg 560.00 USD
Do you need bulk/larger quantities?

CD40 (mouse) monoclonal antibody (FGK45) (preservative free) 

Purified from hybridoma tissue culture supernatant., ELISA, Flow Cytometry, WB, FUNC | Print as PDF
ALX-805-046PF-C100 100 µg 328.00 USD
ALX-805-046PF-C500 500 µg 608.00 USD
Do you need bulk/larger quantities?

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
CD40 Monoclonal antibody
By catalog section:


Technical Service
Customer Service

Related Literature

Stem Cells
Stem Cells
Download as PDF

All new literature pieces