Product Details
Alternative Name: | β2 integrin |
|
Clone: | MEM-148 |
|
Host: | Mouse |
|
Isotype: | IgG1 |
|
Immunogen: | Human peripheral blood mononuclear cells. |
|
UniProt ID: | P05107 |
|
Species reactivity: | Human
|
|
Specificity: | Recognizes free CD18 (β2 integrin) not associated with CD11. |
|
Crossreactivity: | Does not cross-react with pig CD18. |
|
Applications: | Flow Cytometry, IP, WB, FUNC
|
|
Recommended Dilutions/Conditions: | Western Blot (non-reducing) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
|
Application Notes: | Functional Application: induces homotypic cell aggregation and high-affinity LFA-1 conformation in resting leukocytes. |
|
Purity Detail: | Protein A-affinity purified. |
|
Formulation: | Liquid. In PBS, pH 7.4, containing 15 mM sodium azide. |
|
Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
|
Shipping: | Shipped on Blue Ice |
|
Short Term Storage: | +4°C |
|
Long Term Storage: | -20°C |
|
Regulatory Status: | RUO - Research Use Only |
|
Product Literature References
A novel anti-CD18 mAb recognizes an activation-related epitope and induces a high-affinity conformation in leukocyte integrins: K. Drbal, et al.; Immunobiology
203, 687 (2001),
Abstract;
A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells: K. Drbal, et al.; Blood
98, 1561 (2001),
Abstract;
Full Text
Human leukocytes contain a large pool of free forms of CD18: K. Drbal, et al.; BBRC
275, 295 (2000),
Abstract;