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Fas (human) monoclonal antibody (APO-1-1)

 
ALX-805-022-C100 100 µg Purified 325.00 USD
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Product Specification

Alternative Name:CD95, APO-1, TNFRSF 6
 
Clone:APO-1-1
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Human Fas (CD95; APO-1).
 
UniProt ID:P25445
 
Species reactivity:Human
 
Applications:Flow Cytometry, IHC (FS), FUNC
 
Recommended Dilutions/Conditions:Flow Cytometry (1-2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:APO-1-1 (IgG1) is an isotype-switch variant of the original clone APO-1-3 (ALX-805-020). Since undesired side reactions in immunohistochemistry are minimal for IgG1 antibodies, APO-1-1 is especially useful for immunohistology on cryostat sections and on cytospin preparations.
Not suitable for stainings on paraffin sections.
Functional Application: Induces apoptosis upon cross-linking.
 
Formulation:Liquid. In PBS, pH 7.2-7.4.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:+4°C
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Epigenetically Enhanced PDT Induces Significantly Higher Levels of Multiple Extrinsic Pathway Apoptotic Factors than Standard PDT, Resulting in Greater Extrinsic and Overall Apoptosis of Cutaneous T-cell Lymphoma: K.A. Salva, et al.; Photochem. Photobiol. 94, 1058 (2018), Application(s): Multispectral imaging of immunostained cytopreparations, Abstract;
Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms: C.S. Backes, et al.; J. Biol. Chem. 293, 16348 (2018), Abstract; Full Text
Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD): H. Wajant, et al.; J. Biol. Chem. 275, 24357 (2000), Abstract; Full Text
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L): D.C. Huang, et al.; PNAS 96, 14871 (1999), Abstract;
Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells: F. Leithauser, et al.; Lab. Invest. 69, 415 (1993), Abstract;

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