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RIG-I (mouse) monoclonal antibody (SS1A)

ALX-804-960-0100 100 µg 250.00 USD
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Product Details

Alternative Name:RIG-1, Retinoic acid-inducible gene 1 protein, DEAD-box protein 58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 M, Probable ATP-dependent RNA helicase DDX58
Immunogen:Synthetic peptide corresponding to C-terminal mouse RIG-I conjugated to KLH.
UniProt ID:Q6Q899
Gene/Protein Identifier:109906 (Entrez GeneID)
Species reactivity:Mouse
Purity Detail:Affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:RIG-1/DDX58 (Retinoic acid-inducible gene 1 protein/ DEAD-box protein 58) is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kDa. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 and MDA5 (melanoma differentiation-associated gene 5) are key intracellular receptors that sense intracellular viral infection and trigger a signal for innate antiviral responses including the production of typeI IFN. Clone SS1A has been shown to be useful for Western blotting of the mouse RIG-1 protein. Involved in innate immune defense against viruses. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses.
Regulatory Status:RUO - Research Use Only
RIG-I (mouse) monoclonal antibody (SS1A) Western blot
Western blot analysis of RIG-I (mouse), mAb (SS1A) (Prod. No. ALX-804-960) using NIH-3T3 cells extracts (lane 1) and mouse splenocytes (lane 2).
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RIG-I (mouse) monoclonal antibody (SS1A) Western blot

Product Literature References

The Essential Role of Double-Stranded RNA-Dependent Antivira Signaling in the Degradation of Nonself Single-Stranded RNA in Nonimmune Cells: S. Kimura, et al.; J. Immunol. 201, 1044 (2018), Abstract;
Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability: S.E. Dudek, et al. ; Sci. Rep. 6, 27275 (2016), Application(s): Western blot, Abstract; Full Text
Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity: C.S. Ilkow, et al.; Nat. Med. 21, 530 (2015), Application(s): Indirect immunofluorescence microscopy, Immunohistochemistry, Abstract;