| ALX-804-873-C100 | 100 µg | 501.00 USD |  |
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| Alternative Name: | High mobility group protein B1 |
| Clone: | Moby-2 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human HMGB1. |
| UniProt ID: | P09429 |
| Source: | Purified from concentrated hybridoma tissue culture supernatant. |
| Species reactivity: | Human |
| Applications: | ELISA, IP |
| Recommended Dilutions/Conditions: | Immunoprecipitation (1:200) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein G-affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
| Shipping: | Blue Ice |
| Short Term Storage: | +4°C |
| Long Term Storage: | -20°C |
| Scientific Background: | High mobility group 1 protein (HMGB1) is a chromatin component that is either passively released from necrotic cells or actively secreted in response to angiogenic and inflammatory signals. HMGB1 itself may signal through the receptor for advanced glycation end products (RAGE), and via the Toll-like receptors, TLR2 and TLR4. HMGB1 functions as a late mediator of immune response. Apoptotic cells also release HMGB1 but in an oxidized form that does not trigger the immune response. |
| Regulatory Status: | RUO - Research Use Only |
