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SARM (human) monoclonal antibody (Sarmy-1)

ALX-804-831-C100 100 µg 426.00 USD
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Product Details

Alternative Name:TIR-1, Sterile α and TIR motif-containing protein 1, SAM and ARM-containing protein, Sterile α motif and armadillo repeat-containing protein
Immunogen:Recombinant human SARM (aa 93-292).
UniProt ID:Q6SZW1
Source:Purified from concentrated hybridoma tissue culture supernatant.
Species reactivity:Human
Recommended Dilutions/Conditions:Immunoprecipitation (1:200)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Does not work for Western Blot.
Formulation:Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
Handling:Avoid freeze/thaw cycles.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:In mammals, TIR domain adapters, including Myd88, TIRAP, TICAM-1 (also called TRIF), and TRAM, act in Toll-like receptor (TLR) signaling pathway. The last member of this family called SARM (sterile and armadillo motifs) is highly conserved but has no known function in any organism. SARM is the only mammalian TIR-domain adapter proteins conserved in C. elegans, suggesting that SARM is the most ancient member of this class of signaling proteins. Overexpression of SARM fails to activate either NF-kB- or IRF-3-dependent reporter gene expression, two transcription factors that are sensitive to TLR signaling, suggesting that SARM is functionally distinct from other mammalian TIR domain-containing proteins.
Regulatory Status:RUO - Research Use Only

General Literature References

Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response: N.T. Liberati, et al.; PNAS 101, 6593 (2004), Abstract;
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM: C. Couillault, et al.; Nat. Immunol. 5, 488 (2004), Abstract;

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